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Article

Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer’s Disease

1
Department of Radiology, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-Gu, Seoul 05278, Korea
2
Department of Biochemistry and Molecular Biology, Graduate School, Kyung Hee University, 26 Kyung Hee Dae-ro, Dongdaemun-gu, Seoul 02447, Korea
3
Department of Biomedical Engineering, Undergraduate School, College of Electronics and Information, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Seoul 17104, Korea
4
Department of Medicine, College of Medicine, Kyung Hee University, 26 Kyung Hee Dae-ro, Dongdaemun-gu, Seoul 02447, Korea
5
Department of Neurology, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, Korea
6
Department of Laboratory Medicine, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, Korea
7
Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, 26 Kyung Hee Dae-ro, Dongdaemun-gu, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Benedetta Nacmias
Diagnostics 2021, 11(5), 740; https://doi.org/10.3390/diagnostics11050740
Received: 21 March 2021 / Revised: 15 April 2021 / Accepted: 19 April 2021 / Published: 21 April 2021
(This article belongs to the Special Issue Diagnosis and Management of Alzheimer's Disease)
Cyclophilin A (CypA), heme oxygenase-1 (HO-1), and inositol-requiring enzyme 1 (IRE1) are believed to be associated with Alzheimer’s disease (AD). In this study, we investigated the association between gray matter volume (GMV) changes and blood levels of CypA, HO-1, and IRE1 in cognitively normal (CN) subjects and those with amnestic mild cognitive impairment (aMCI) and AD. Forty-five elderly CN, 34 aMCI, and 39 AD subjects were enrolled in this study. The results of voxel-based multiple regression analysis showed that blood levels of CypA, HO-1, and IRE1 were correlated with GMV on brain magnetic resonance imaging (MRI) in the entire population (p = 0.0005). The three serum protein levels were correlated with GMV of signature AD regions in the population as a whole. CypA values increased with increasing GMV in the occipital gyrus (r = 0.387, p < 0.0001) and posterior cingulate (r = 0.196, p = 0.034). HO-1 values increased with increasing GMV at the uncus (r = 0.307, p = 0.0008), lateral globus pallidus and putamen (r = 0.287, p = 0.002), and hippocampus (r = 0.197, p = 0.034). IRE1 values decreased with increasing GMV at the uncus (r = −0.239, p = 0.010) and lateral globus pallidus and putamen (r = −0.335, p = 0.0002). Associations between the three serum protein levels and regional GMV indicate that the blood levels of these biomarkers may reflect the pathological mechanism of AD in the brain. View Full-Text
Keywords: Alzheimer′s disease; gray matter volume; blood-based biomarker; heme oxygenase-1; inositol-requiring enzyme 1; cyclophilin A Alzheimer′s disease; gray matter volume; blood-based biomarker; heme oxygenase-1; inositol-requiring enzyme 1; cyclophilin A
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MDPI and ACS Style

Choi, H.-I.; Kim, K.; Lee, J.; Chang, Y.; Rhee, H.Y.; Park, S.; Lee, W.-I.; Choe, W.; Ryu, C.-W.; Jahng, G.-H. Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer’s Disease. Diagnostics 2021, 11, 740. https://doi.org/10.3390/diagnostics11050740

AMA Style

Choi H-I, Kim K, Lee J, Chang Y, Rhee HY, Park S, Lee W-I, Choe W, Ryu C-W, Jahng G-H. Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer’s Disease. Diagnostics. 2021; 11(5):740. https://doi.org/10.3390/diagnostics11050740

Chicago/Turabian Style

Choi, Hyon-Il, Kiyoon Kim, Jiyoon Lee, Yunjung Chang, Hak Y. Rhee, Soonchan Park, Woo-In Lee, Wonchae Choe, Chang-Woo Ryu, and Geon-Ho Jahng. 2021. "Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer’s Disease" Diagnostics 11, no. 5: 740. https://doi.org/10.3390/diagnostics11050740

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