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Open AccessReview

Point of Care Diagnostics in the Age of COVID-19

1
School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
2
Institute for Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia
3
SUStech-UTS Joint Research Centre for Biomedical Materials & Devices, Southern University of Science and Technology, Shenzhen 518055, China
4
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University Sydney, Sydney, NSW 2109, Australia
5
School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia
6
Institute of Molecular Medicine, Sechenov University, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 9; https://doi.org/10.3390/diagnostics11010009
Received: 15 October 2020 / Revised: 19 December 2020 / Accepted: 20 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Advanced Diagnostic Kit Development for Laboratory Diagnosis)
The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been overwhelmed with an exponential spread of the virus and surge in the number of confirmed COVID-19 cases. Current standard diagnostic methods are inadequate for widespread testing as they suffer from prolonged turn-around times (>12 h) and mostly rely on high-biosafety-level laboratories and well-trained technicians. Point-of-care (POC) tests have the potential to vastly improve healthcare in several ways, ranging from enabling earlier detection and easier monitoring of disease to reaching remote populations. In recent years, the field of POC diagnostics has improved markedly with the advent of micro- and nanotechnologies. Due to the COVID-19 pandemic, POC technologies have been rapidly innovated to address key limitations faced in existing standard diagnostic methods. This review summarizes and compares the latest available POC immunoassay, nucleic acid-based and clustered regularly interspaced short palindromic repeats- (CRISPR)-mediated tests for SARS-CoV-2 detection that we anticipate aiding healthcare facilities to control virus infection and prevent subsequent spread. View Full-Text
Keywords: SARS-CoV-2; COVID-19; point of care testing; respiratory diseases SARS-CoV-2; COVID-19; point of care testing; respiratory diseases
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MDPI and ACS Style

Rezaei, M.; Razavi Bazaz, S.; Zhand, S.; Sayyadi, N.; Jin, D.; Stewart, M.P.; Ebrahimi Warkiani, M. Point of Care Diagnostics in the Age of COVID-19. Diagnostics 2021, 11, 9. https://doi.org/10.3390/diagnostics11010009

AMA Style

Rezaei M, Razavi Bazaz S, Zhand S, Sayyadi N, Jin D, Stewart MP, Ebrahimi Warkiani M. Point of Care Diagnostics in the Age of COVID-19. Diagnostics. 2021; 11(1):9. https://doi.org/10.3390/diagnostics11010009

Chicago/Turabian Style

Rezaei, Meysam; Razavi Bazaz, Sajad; Zhand, Sareh; Sayyadi, Nima; Jin, Dayong; Stewart, Martin P.; Ebrahimi Warkiani, Majid. 2021. "Point of Care Diagnostics in the Age of COVID-19" Diagnostics 11, no. 1: 9. https://doi.org/10.3390/diagnostics11010009

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