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Article

Histopathological Ratios to Predict Gleason Score Agreement between Biopsy and Radical Prostatectomy

1
Institute of Pathology, Università Cattolica del S. Cuore, Fondazione Policlinico “A. Gemelli”, 00168 Rome, Italy
2
Institute of Medical Oncology, Università Cattolica del S. Cuore, Fondazione Policlinico “A. Gemelli”, 00168 Rome, Italy
3
Institute of Urology, Università Cattolica del S. Cuore, Fondazione Policlinico “A. Gemelli”, 00168 Rome, Italy
4
Department of Radiology, Università Cattolica del S. Cuore, Fondazione Policlinico “A. Gemelli”, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
V.F. and M.M. share equal contribution.
Senior authorship.
Diagnostics 2021, 11(1), 10; https://doi.org/10.3390/diagnostics11010010
Received: 13 October 2020 / Revised: 17 December 2020 / Accepted: 18 December 2020 / Published: 23 December 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Biopsy proven Gleason score is essential to decide treatment modalities for prostate cancer, either surgical (radical prostatectomy) or non-surgical (active surveillance, watchful waiting, radiation therapy and hormone therapy). Several studies indicated that biopsy proven Gleason score may underestimate Gleason score at radical prostatectomy, hence we aimed to calculate the minimum length of biopsy cores needed to have Gleason score agreement. We evaluated 115 prostate cancer patients who underwent multiparametric magnetic resonance/transperineal ultrasonography fusion biopsy and subsequently, radical prostatectomy. Biopsy proven Gleason score was consistent with Gleason score at subsequent radical prostatectomy in 82.6% of patients, while in 17.4% of patients, Gleason score was higher at radical prostatectomy. Gleason score agreement showed a strong direct association with a ratio > 0.05 between the total volume of biopsies performed in tumor area and the volume of the corresponding tumor at radical prostatectomy. A significant association was also found with a ratio ≥ 0.0034 between the tumor volume in the biopsy and the volume of the corresponding tumor at radical prostatectomy and with a ratio ≥ 0.086 between the tumor volume in the biopsy and the total volume of biopsies performed in the tumor area. These results could be exploited to calculate the minimum length of biopsy cores needed to have a correct Gleason score estimation and therefore be used in fusion targeted biopsies with volume adjustments. View Full-Text
Keywords: active surveillance; Gleason score; needle biopsy; prostate cancer; radical prostatectomy active surveillance; Gleason score; needle biopsy; prostate cancer; radical prostatectomy
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MDPI and ACS Style

Fiorentino, V.; Martini, M.; Dell’Aquila, M.; Musarra, T.; Orticelli, E.; Larocca, L.M.; Rossi, E.; Totaro, A.; Pinto, F.; Lenci, N.; Di Paola, V.; Manfredi, R.; Bassi, P.F.; Pierconti, F. Histopathological Ratios to Predict Gleason Score Agreement between Biopsy and Radical Prostatectomy. Diagnostics 2021, 11, 10. https://doi.org/10.3390/diagnostics11010010

AMA Style

Fiorentino V, Martini M, Dell’Aquila M, Musarra T, Orticelli E, Larocca LM, Rossi E, Totaro A, Pinto F, Lenci N, Di Paola V, Manfredi R, Bassi PF, Pierconti F. Histopathological Ratios to Predict Gleason Score Agreement between Biopsy and Radical Prostatectomy. Diagnostics. 2021; 11(1):10. https://doi.org/10.3390/diagnostics11010010

Chicago/Turabian Style

Fiorentino, Vincenzo; Martini, Maurizio; Dell’Aquila, Marco; Musarra, Teresa; Orticelli, Ersilia; Larocca, Luigi M.; Rossi, Ernesto; Totaro, Angelo; Pinto, Francesco; Lenci, Niccolò; Di Paola, Valerio; Manfredi, Riccardo; Bassi, Pier F.; Pierconti, Francesco. 2021. "Histopathological Ratios to Predict Gleason Score Agreement between Biopsy and Radical Prostatectomy" Diagnostics 11, no. 1: 10. https://doi.org/10.3390/diagnostics11010010

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