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Volume 11
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10.3390/diagnostics11010145
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Review

Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

by
Nurruzanna Ismail
,
Noraidatulakma Abdullah
,
Nor Azian Abdul Murad
,
Rahman Jamal
and
Siti Aishah Sulaiman
*
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, Malaysia
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 145; https://doi.org/10.3390/diagnostics11010145
Submission received: 30 December 2020 / Revised: 14 January 2021 / Accepted: 18 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue The Diagnostic and Therapeutic Value of RNAs in Human Diseases)
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Abstract

The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
Keywords: long noncoding RNA; cardiovascular disease; type 2 diabetes; biomarker; diagnosis; insulin secretion long noncoding RNA; cardiovascular disease; type 2 diabetes; biomarker; diagnosis; insulin secretion

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MDPI and ACS Style

Ismail, N.; Abdullah, N.; Abdul Murad, N.A.; Jamal, R.; Sulaiman, S.A. Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics 2021, 11, 145. https://doi.org/10.3390/diagnostics11010145

AMA Style

Ismail N, Abdullah N, Abdul Murad NA, Jamal R, Sulaiman SA. Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics. 2021; 11(1):145. https://doi.org/10.3390/diagnostics11010145

Chicago/Turabian Style

Ismail, Nurruzanna, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal, and Siti Aishah Sulaiman. 2021. "Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes" Diagnostics 11, no. 1: 145. https://doi.org/10.3390/diagnostics11010145

APA Style

Ismail, N., Abdullah, N., Abdul Murad, N. A., Jamal, R., & Sulaiman, S. A. (2021). Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics, 11(1), 145. https://doi.org/10.3390/diagnostics11010145

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