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Volume 10
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10.3390/diagnostics10050275
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Article

Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience

by
Mee-seon Kim
1,
Tae In Park
2,
Shin-Ah Son
3 and
Hyoun Wook Lee
4,*
1
Department of Pathology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
2
Department of Pathology, Kyungpook National University School of Medicine, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea
3
Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
4
Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Korea
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(5), 275; https://doi.org/10.3390/diagnostics10050275
Submission received: 14 April 2020 / Revised: 26 April 2020 / Accepted: 29 April 2020 / Published: 2 May 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
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Abstract

Indolamine-2,3-dioxygenase (IDO) is an intracellular enzyme that catalyzes amino acid tryptophan to L-kynurenine. IDO is overexpressed in various cancers and several IDO inhibitors have been assessed in multiple clinical trials. If an IDO inhibitor is to be commercialized, IDO immunohistochemistry will be an important method. In this study, 80% (28/35) of mature T- and natural killer (NK)-cell neoplasms showed positivity for IDO protein (score 1: five, score 2: one, score 3: seven, score 4: fifteen). In addition, 29.9% (23/77) of mature B-cell lymphomas showed positivity for IDO protein (score 1: three, score 2: tewelve, score 3: four, score 4: four). In mature B-cell lymphomas, 95.7% (22/23) of IDO positive cases were diffuse B-cell lymphomas. Our study includes various types of lymphoma that were previously unreported and shows various patterns of IDO stain according to the type. When the results are accumulated, IDO immunohistochemistry will be a useful tool to diagnose lymphomas and to predict their prognosis.
Keywords: Indolamine-2,3-dioxygenase (IDO); lymphoma; immunohistochemistry (IHC) Indolamine-2,3-dioxygenase (IDO); lymphoma; immunohistochemistry (IHC)

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MDPI and ACS Style

Kim, M.-s.; Park, T.I.; Son, S.-A.; Lee, H.W. Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience. Diagnostics 2020, 10, 275. https://doi.org/10.3390/diagnostics10050275

AMA Style

Kim M-s, Park TI, Son S-A, Lee HW. Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience. Diagnostics. 2020; 10(5):275. https://doi.org/10.3390/diagnostics10050275

Chicago/Turabian Style

Kim, Mee-seon, Tae In Park, Shin-Ah Son, and Hyoun Wook Lee. 2020. "Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience" Diagnostics 10, no. 5: 275. https://doi.org/10.3390/diagnostics10050275

APA Style

Kim, M.-s., Park, T. I., Son, S.-A., & Lee, H. W. (2020). Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience. Diagnostics, 10(5), 275. https://doi.org/10.3390/diagnostics10050275

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