Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AA | Avascular Area |
ACPA | Anticitrullinated Protein Antibody |
AD | Autoimmune Disease |
ALT | Alanine Transaminase |
ANA | Antinuclear Antibody |
ANCA | Antineutrophil Cytoplasmic Antibody |
ASAS | Antisynthetase Antibodies Syndrome |
AST | Aspartate Transaminase |
BC | Bushy capillary |
CPK | Creatine Phosphokinase |
CTD | Connective Tissue Disease |
DsDNA | Anti-Double-Strain DNA |
ENA | Extractable Nuclear Antigens |
ESR | Erythrocyte Sedimentation Rate |
GC | Giant Capillary |
HRCT | High-Resolution Computed Tomography |
IIM | Idiopathic Inflammatory Myopathies |
ILD | Interstitial Lung Disease |
IPAF | Interstitial Pneumonia with Autoimmune Features |
IPF | Idiopathic Pulmonary Fibrosis |
LDH | Lactic Dehydrogenase |
MDT | Multidisciplinary Team |
NSIP | Nonspecific Interstitial Pneumonia |
NVC | Nailfold Videocapillaroscopy |
PMR | Polymyalgia Rheumatica |
pSS | Primary Sjӧgren’s Syndrome |
RP | Raynaud’s Phenomenon |
SSc | Systemic Sclerosis |
UIP | Usual Interstitial Pneumonia |
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General Features | HRCT Pattern | Final Diagnosis | |||
---|---|---|---|---|---|
Number (% Female) | 361 (52%) | NSIP | 39.3% | IPF | 24.3% |
Age | 66.6 (±10.8) | OP | 7.2% | HP | 4.2% |
RP | 95 (26.3%) | UIPp | 12.5% | Exposure | 5% |
NVC + | 64 (17.7%) | UIP | 24.6% | IIMs (PM/DM+ASAS) | 8.6% (3.9% + 4.7%) |
CPFE | 4.7% | SSDs (SSc+MCTD) | 8.3% (7.7% + 0.5%) | ||
DIP | 3% | RA | 6.6% | ||
LIP | 0.6% | pSS | 4.7% | ||
Undetermined | 10.2% | SLE | 0.5% | ||
Combined # | 0.9% | Overlap § | 2.2% | ||
IPAF | 17.5% | ||||
Other * | 0.8% | ||||
Cryptogenic | 17.7% |
Items | NVC+Patients | NVC-Patients | p |
---|---|---|---|
Number | 64 | 297 | |
Mean Age (± SD) | 61.4 ± 13.3 | 67.8 ± 9.8 | 0.001 |
Female% | 65.6 | 49.1 | 0.01 |
RP% | 68.7 | 17.1 | <0.0001 |
HRCT patterns% | |||
NSIP | 51.5 | 36.4 | 0.02 |
OP | 3.1 | 8 | n.s. |
NSIP+OP | 0 | 0.4 | n.s. |
UIP | 18.75 | 25.9 | n.s. |
UIP+OP | 1.5 | 0.4 | n.s. |
UIPp | 9.4 | 13.1 | n.s. |
CPFE | 1.5 | 5.4 | n.s. |
DIP | 1.5 | 3.4 | n.s. |
LIP | 1.5 | 0.4 | n.s. |
Indeterminate | 10.9 | 6.7 | n.s. |
Final Diagnosis% | |||
SSDs | 45.3 | 1 | <0.0001 |
IIMs | 25 | 6.4 | <0.0001 |
Other CTDs # | 6.2 | 13.5 | n.s. |
IPAF | 10.9 | 19.5 | n.s. |
IPF | 7.8 | 27.9 | 0.0007 |
Other * | 3 | 31.6 | <0.0001 |
Patients | RP | ILD/PAH | T | FTLs | Skin | Abs | NVC+ | Total |
---|---|---|---|---|---|---|---|---|
P1 | 0 | 2 | 2 | 3 | 0 | 0 | 2 | 9 |
P2 | 3 | 2 | 0 | 3 | 0 | 0 | 2 | 10 |
P3 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P4 | 3 | 2 | 2 | 0 | 0 | 0 | 2 | 9 |
P5 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P6 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P7 | 3 | 2 | 0 | 0 | 0 | 3 | 2 | 10 |
P8 | 3 | 2 | 0 | 0 | 0 | 3 | 2 | 10 |
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Sambataro, D.; Sambataro, G.; Libra, A.; Vignigni, G.; Pino, F.; Fagone, E.; Fruciano, M.; Gili, E.; Pignataro, F.; Del Papa, N.; et al. Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients. Diagnostics 2020, 10, 253. https://doi.org/10.3390/diagnostics10050253
Sambataro D, Sambataro G, Libra A, Vignigni G, Pino F, Fagone E, Fruciano M, Gili E, Pignataro F, Del Papa N, et al. Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients. Diagnostics. 2020; 10(5):253. https://doi.org/10.3390/diagnostics10050253
Chicago/Turabian StyleSambataro, Domenico, Gianluca Sambataro, Alessandro Libra, Giovanna Vignigni, Fabio Pino, Evelina Fagone, Mary Fruciano, Elisa Gili, Francesca Pignataro, Nicoletta Del Papa, and et al. 2020. "Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients" Diagnostics 10, no. 5: 253. https://doi.org/10.3390/diagnostics10050253
APA StyleSambataro, D., Sambataro, G., Libra, A., Vignigni, G., Pino, F., Fagone, E., Fruciano, M., Gili, E., Pignataro, F., Del Papa, N., & Vancheri, C. (2020). Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients. Diagnostics, 10(5), 253. https://doi.org/10.3390/diagnostics10050253