Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AA | Avascular Area |
ACPA | Anticitrullinated Protein Antibody |
AD | Autoimmune Disease |
ALT | Alanine Transaminase |
ANA | Antinuclear Antibody |
ANCA | Antineutrophil Cytoplasmic Antibody |
ASAS | Antisynthetase Antibodies Syndrome |
AST | Aspartate Transaminase |
BC | Bushy capillary |
CPK | Creatine Phosphokinase |
CTD | Connective Tissue Disease |
DsDNA | Anti-Double-Strain DNA |
ENA | Extractable Nuclear Antigens |
ESR | Erythrocyte Sedimentation Rate |
GC | Giant Capillary |
HRCT | High-Resolution Computed Tomography |
IIM | Idiopathic Inflammatory Myopathies |
ILD | Interstitial Lung Disease |
IPAF | Interstitial Pneumonia with Autoimmune Features |
IPF | Idiopathic Pulmonary Fibrosis |
LDH | Lactic Dehydrogenase |
MDT | Multidisciplinary Team |
NSIP | Nonspecific Interstitial Pneumonia |
NVC | Nailfold Videocapillaroscopy |
PMR | Polymyalgia Rheumatica |
pSS | Primary Sjӧgren’s Syndrome |
RP | Raynaud’s Phenomenon |
SSc | Systemic Sclerosis |
UIP | Usual Interstitial Pneumonia |
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General Features | HRCT Pattern | Final Diagnosis | |||
---|---|---|---|---|---|
Number (% Female) | 361 (52%) | NSIP | 39.3% | IPF | 24.3% |
Age | 66.6 (±10.8) | OP | 7.2% | HP | 4.2% |
RP | 95 (26.3%) | UIPp | 12.5% | Exposure | 5% |
NVC + | 64 (17.7%) | UIP | 24.6% | IIMs (PM/DM+ASAS) | 8.6% (3.9% + 4.7%) |
CPFE | 4.7% | SSDs (SSc+MCTD) | 8.3% (7.7% + 0.5%) | ||
DIP | 3% | RA | 6.6% | ||
LIP | 0.6% | pSS | 4.7% | ||
Undetermined | 10.2% | SLE | 0.5% | ||
Combined # | 0.9% | Overlap § | 2.2% | ||
IPAF | 17.5% | ||||
Other * | 0.8% | ||||
Cryptogenic | 17.7% |
Items | NVC+Patients | NVC-Patients | p |
---|---|---|---|
Number | 64 | 297 | |
Mean Age (± SD) | 61.4 ± 13.3 | 67.8 ± 9.8 | 0.001 |
Female% | 65.6 | 49.1 | 0.01 |
RP% | 68.7 | 17.1 | <0.0001 |
HRCT patterns% | |||
NSIP | 51.5 | 36.4 | 0.02 |
OP | 3.1 | 8 | n.s. |
NSIP+OP | 0 | 0.4 | n.s. |
UIP | 18.75 | 25.9 | n.s. |
UIP+OP | 1.5 | 0.4 | n.s. |
UIPp | 9.4 | 13.1 | n.s. |
CPFE | 1.5 | 5.4 | n.s. |
DIP | 1.5 | 3.4 | n.s. |
LIP | 1.5 | 0.4 | n.s. |
Indeterminate | 10.9 | 6.7 | n.s. |
Final Diagnosis% | |||
SSDs | 45.3 | 1 | <0.0001 |
IIMs | 25 | 6.4 | <0.0001 |
Other CTDs # | 6.2 | 13.5 | n.s. |
IPAF | 10.9 | 19.5 | n.s. |
IPF | 7.8 | 27.9 | 0.0007 |
Other * | 3 | 31.6 | <0.0001 |
Patients | RP | ILD/PAH | T | FTLs | Skin | Abs | NVC+ | Total |
---|---|---|---|---|---|---|---|---|
P1 | 0 | 2 | 2 | 3 | 0 | 0 | 2 | 9 |
P2 | 3 | 2 | 0 | 3 | 0 | 0 | 2 | 10 |
P3 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P4 | 3 | 2 | 2 | 0 | 0 | 0 | 2 | 9 |
P5 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P6 | 3 | 2 | 0 | 0 | 2 | 0 | 2 | 9 |
P7 | 3 | 2 | 0 | 0 | 0 | 3 | 2 | 10 |
P8 | 3 | 2 | 0 | 0 | 0 | 3 | 2 | 10 |
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Sambataro, D.; Sambataro, G.; Libra, A.; Vignigni, G.; Pino, F.; Fagone, E.; Fruciano, M.; Gili, E.; Pignataro, F.; Del Papa, N.; et al. Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients. Diagnostics 2020, 10, 253. https://doi.org/10.3390/diagnostics10050253
Sambataro D, Sambataro G, Libra A, Vignigni G, Pino F, Fagone E, Fruciano M, Gili E, Pignataro F, Del Papa N, et al. Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients. Diagnostics. 2020; 10(5):253. https://doi.org/10.3390/diagnostics10050253
Chicago/Turabian StyleSambataro, Domenico, Gianluca Sambataro, Alessandro Libra, Giovanna Vignigni, Fabio Pino, Evelina Fagone, Mary Fruciano, Elisa Gili, Francesca Pignataro, Nicoletta Del Papa, and et al. 2020. "Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients" Diagnostics 10, no. 5: 253. https://doi.org/10.3390/diagnostics10050253