Next Article in Journal
Comparative Study Regarding the Properties of Methylene Blue and Proflavine and Their Optimal Concentrations for In Vitro and In Vivo Applications
Next Article in Special Issue
Clinical and Genotypical Features of False-Negative Patients in 26 Years of Cystic Fibrosis Neonatal Screening in Tuscany, Italy
Previous Article in Journal
Benign Biliary Strictures: A Systematic Review on Endoscopic Treatment Options
Open AccessArticle

Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

Dipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, 80131 Naples, Italy
Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples Federico II, 80131 Naples, Italy
Dipartimento di Scienze e Tecnologie, University of Naples Parthenope, 80133 Naples, Italy
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, 80138 Naples, Italy
CEINGE-Biotecnologie Avanzate, 80145 Naples, Italy
Dipartimento di Medicina Clinica e Sperimentale, University of Foggia, 71122 Foggia, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2020, 10(4), 222;
Received: 10 March 2020 / Revised: 31 March 2020 / Accepted: 13 April 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Diagnosis and Management of Cystic Fibrosis)
About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and Pseudomonas aeruginosa or Stenotrophomonas maltophilia colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels. View Full-Text
Keywords: cystic fibrosis; inferior turbinates hypertrophy; nasal polyposis; salivary cytokines cystic fibrosis; inferior turbinates hypertrophy; nasal polyposis; salivary cytokines
Show Figures

Figure 1

MDPI and ACS Style

Castaldo, A.; Iacotucci, P.; Carnovale, V.; Cimino, R.; Liguori, R.; Comegna, M.; Raia, V.; Corso, G.; Castaldo, G.; Gelzo, M. Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis. Diagnostics 2020, 10, 222.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop