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Open AccessArticle

Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal

1
Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91058 Erlangen-Tennenlohe, Germany
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Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center-University of Freiburg, 79110 Freiburg, Germany
3
Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany
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Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, 79104 Freiburg, Germany
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Institute of Neuropathology, Justus-Liebig-University Giessen, 35392 Giessen, Germany
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Institute of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany
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Department of Hematology, Oncology and Immunology, Philipps-University Marburg, and University Hospital Gießen and Marburg, Marburg, Germany Baldingerstraße
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Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany
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Heinrich-Lanz-Center for digital health, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany
10
Pediatric Hematology/Oncology, Children’s Hospital, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany
11
University Cancer Center (UCT) of the University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany
12
Institute of Human Genetics, University Hospital Magdeburg, Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany
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Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, Germany
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German Cancer Consortium (DKTK), partner site Freiburg, 79106 Freiburg, Germany
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Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
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Department of Medicine 2, Hematology/Oncology, Goethe University Hospital, 60590 Frankfurt am Main, Germany
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Institute of Experimental Dermatology and Institute of Cardiogenetics, University of Lübeck, 23562 Lübeck, Germany
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Comprehensive Cancer Center Freiburg (CCCF), Faculty of Medicine and Medical Center – University of Freiburg, 79106 Freiburg, Germany
19
German Cancer Consortium (DKTK), partner site Freiburg
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2020, 10(2), 93; https://doi.org/10.3390/diagnostics10020093
Received: 15 December 2019 / Revised: 21 January 2020 / Accepted: 7 February 2020 / Published: 10 February 2020
(This article belongs to the Special Issue Point-of-Care Detection Devices for Healthcare)
Clinicians in molecular tumor boards (MTB) are confronted with a growing amount of genetic high-throughput sequencing data. Today, at German university hospitals, these data are usually handled in complex spreadsheets from which clinicians have to obtain the necessary information. The aim of this work was to gather a comprehensive list of requirements to be met by cBioPortal to support processes in MTBs according to clinical needs. Therefore, oncology experts at nine German university hospitals were surveyed in two rounds of interviews. To generate an interview guideline a scoping review was conducted. For visual support in the second round, screenshot mockups illustrating the requirements from the first round were created. Requirements that cBioPortal already meets were skipped during the second round. In the end, 24 requirements with sometimes several conceivable options were identified and 54 screenshot mockups were created. Some of the identified requirements have already been suggested to the community by other users or are currently being implemented in cBioPortal. This shows, that the results are in line with the needs expressed by various disciplines. According to our findings, cBioPortal has the potential to significantly improve the processes and analyses of an MTB after the implementation of the identified requirements.
Keywords: decision making, computer-assisted; decision support systems, clinical; precision medicine; computational biology; molecular tumor board; cBioPortal; requirements analysis; neoplasms decision making, computer-assisted; decision support systems, clinical; precision medicine; computational biology; molecular tumor board; cBioPortal; requirements analysis; neoplasms
MDPI and ACS Style

Buechner, P.; Hinderer, M.; Unberath, P.; Metzger, P.; Boeker, M.; Acker, T.; Haller, F.; Mack, E.; Nowak, D.; Paret, C.; Schanze, D.; von Bubnoff, N.; Wagner, S.; Busch, H.; Boerries, M.; Christoph, J. Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. Diagnostics 2020, 10, 93.

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