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Diagnostic Performance of 18F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis

1
Department of Oncology and Hematology, Cantonal Hospital Baden, CH-5404 Baden, Switzerland
2
Clinic of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland
3
Nuclear Medicine, University of Brescia and Spedali Civili Brescia, IT-25123 Brescia, Italy
4
Department of Haematology and Oncology, Niguarda Hospital, IT-20162 Milan, Italy
5
Academic Education Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland
6
Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), CH-6900 Lugano, Switzerland
7
Clinic of Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6900 Lugano, Switzerland
8
Institute of Oncology Research, CH-6500 Bellinzona, Switzerland
9
Department of Nuclear Medicine and Molecular Imaging, University of Lausanne and Lausanne University Hospital, CH-1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2020, 10(2), 101; https://doi.org/10.3390/diagnostics10020101
Received: 13 January 2020 / Revised: 9 February 2020 / Accepted: 11 February 2020 / Published: 12 February 2020
(This article belongs to the Section Medical Imaging)
Background: Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD). As there is no clear consensus about the diagnostic accuracy of these imaging methods, we performed a meta-analysis on this topic. Methods: A comprehensive computer literature search of PubMed, Embase, and Cochrane library databases through December 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR−), and diagnostic odds ratio (DOR) of 18F-FDG PET or PET/CT for detection of PTLD were calculated. Results: Five studies reporting data on the diagnostic performance of 18F-FDG PET or PET/CT in 336 transplant recipients were included in the systematic review and bivariate meta-analysis. Pooled sensitivity and specificity for detection of PTLD were 89.7% (95% confidence interval (95%CI): 84.6–93.2%) and 90.9% (95%CI: 85.9–94.3%), respectively. Pooled LR+, LR−, and DOR were 8.9 (95%CI: 5.7–14), 0.13 (95%CI: 0.08–0.2), and 70.4 (95%CI: 35.4–140), respectively. A significant heterogeneity among studies was not detected. Conclusions: Despite limited literature data, 18F-FDG PET or PET/CT demonstrated good diagnostic performance for the detection of PTLD, but large prospective studies are needed to strengthen these findings. View Full-Text
Keywords: PET; 18F-FDG; PTLD; lymphoma; post-transplant lymphoproliferative disorder; meta-analysis PET; 18F-FDG; PTLD; lymphoma; post-transplant lymphoproliferative disorder; meta-analysis
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MDPI and ACS Style

Ballova, V.; Muoio, B.; Albano, D.; Bertagna, F.; Canziani, L.; Ghielmini, M.; Ceriani, L.; Treglia, G. Diagnostic Performance of 18F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis. Diagnostics 2020, 10, 101. https://doi.org/10.3390/diagnostics10020101

AMA Style

Ballova V, Muoio B, Albano D, Bertagna F, Canziani L, Ghielmini M, Ceriani L, Treglia G. Diagnostic Performance of 18F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis. Diagnostics. 2020; 10(2):101. https://doi.org/10.3390/diagnostics10020101

Chicago/Turabian Style

Ballova, Veronika, Barbara Muoio, Domenico Albano, Francesco Bertagna, Luca Canziani, Michele Ghielmini, Luca Ceriani, and Giorgio Treglia. 2020. "Diagnostic Performance of 18F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis" Diagnostics 10, no. 2: 101. https://doi.org/10.3390/diagnostics10020101

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