Next Article in Journal
Evaluation of SARS-CoV-2 Serological Testing in Patients with Multiple Myeloma and Other Hematologic Malignancies on Monoclonal Antibody Therapies
Previous Article in Journal
Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients
Article

Usefulness of the IgA and IgG Responses to Macrophage Migration Inhibitory Factor for the Diagnosis of Tuberculosis

1
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul 04564, Korea
2
Department of Biomedical Sciences, Microbiology and Immunology and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(11), 991; https://doi.org/10.3390/diagnostics10110991
Received: 22 September 2020 / Revised: 21 October 2020 / Accepted: 20 November 2020 / Published: 23 November 2020
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
Serological tests offer the potential in order to improve the diagnosis of tuberculosis (TB). Macrophage migration inhibitory factor (MIF) plays a protective role in infection control in TB; however, to date, no studies on antibody responses to MIF have been reported. We measured immunoglobulin (Ig)A and IgG responses to MIF in individuals with either active tuberculosis (ATB; n = 65), latent tuberculosis (LTBI; n = 53), or in non-infected individuals (NI; n = 62). The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was used in order to screen for LTBI. The level of IgA against MIF was significantly lower in LTBI and ATB patients than in NI individuals, was significantly related to LTBI and ATB diagnosis, and it could discriminate between LTBI and ATB. In contrast, the level of IgG against MIF was significantly lower in LTBI patients than in NI individuals and was significantly related to LTBI diagnosis. Anti-MIF IgG levels were significantly lower in AFB-negative TB, minimal TB, and new ATB patients, than in the NI group. IgA and IgG levels against MIF both showed significant negative correlations with IFN-γ levels, as assessed using the QFT-GIT test. Although none of the antibodies could achieve high diagnostic predictive power individually, our results suggest the possibility of using IgA antibody responses to MIF in the diagnosis of LTBI and ATB. View Full-Text
Keywords: tuberculosis; serology; diagnosis; biomarkers; macrophage migration inhibitory factor; cytokines tuberculosis; serology; diagnosis; biomarkers; macrophage migration inhibitory factor; cytokines
Show Figures

Figure 1

MDPI and ACS Style

Lee, J.Y.; Kim, B.-J.; Kim, J.-m.; Kim, J.; Joh, J.-S.; Jeong, I.; Kook, Y.-H.; Kim, B.-J. Usefulness of the IgA and IgG Responses to Macrophage Migration Inhibitory Factor for the Diagnosis of Tuberculosis. Diagnostics 2020, 10, 991. https://doi.org/10.3390/diagnostics10110991

AMA Style

Lee JY, Kim B-J, Kim J-m, Kim J, Joh J-S, Jeong I, Kook Y-H, Kim B-J. Usefulness of the IgA and IgG Responses to Macrophage Migration Inhibitory Factor for the Diagnosis of Tuberculosis. Diagnostics. 2020; 10(11):991. https://doi.org/10.3390/diagnostics10110991

Chicago/Turabian Style

Lee, Ji Y., Byoung-Jun Kim, Jee-min Kim, Junghyun Kim, Joon-Sung Joh, Ina Jeong, Yoon-Hoh Kook, and Bum-Joon Kim. 2020. "Usefulness of the IgA and IgG Responses to Macrophage Migration Inhibitory Factor for the Diagnosis of Tuberculosis" Diagnostics 10, no. 11: 991. https://doi.org/10.3390/diagnostics10110991

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop