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Review

Rapid Detection of Methicillin-Resistant Staphylococcus aureus Directly from Blood for the Diagnosis of Bloodstream Infections: A Mini-Review

1
Department of Medicine, Campus Biomedico University, Via Alvaro del Portillo 200, 00128 Rome, Italy
2
Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio” University of Chieti-Pescara, Via Vestini 31, 66100 Chieti, Italy
3
Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, Via Luigi Polacchi 11, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(10), 830; https://doi.org/10.3390/diagnostics10100830
Received: 13 August 2020 / Revised: 22 September 2020 / Accepted: 14 October 2020 / Published: 15 October 2020
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
Staphylococcus aureus represents a major human pathogen able to cause a number of infections, especially bloodstream infections (BSI). Clinical use of methicillin has led to the emergence of methicillin-resistant S. aureus (MRSA) and MRSA-BSI have been reported to be associated with high morbidity and mortality. Clinical diagnosis of BSI is based on the results from blood culture that, although considered the gold standard method, is time-consuming. For this reason, rapid diagnostic tests to identify the presence of methicillin-susceptible S. aureus (MSSA) and MRSA isolates directly in blood cultures are being used with increasing frequency to rapidly commence targeted antimicrobial therapy, also in the light of antimicrobial stewardship efforts. Here, we review and report the most common rapid non-molecular and molecular methods currently available to detect the presence of MRSA directly from blood. View Full-Text
Keywords: Staphylococcus aureus; methicillin resistance; bloodstream infections; rapid tests Staphylococcus aureus; methicillin resistance; bloodstream infections; rapid tests
MDPI and ACS Style

Buonomini, A.R.; Riva, E.; Di Bonaventura, G.; Gherardi, G. Rapid Detection of Methicillin-Resistant Staphylococcus aureus Directly from Blood for the Diagnosis of Bloodstream Infections: A Mini-Review. Diagnostics 2020, 10, 830. https://doi.org/10.3390/diagnostics10100830

AMA Style

Buonomini AR, Riva E, Di Bonaventura G, Gherardi G. Rapid Detection of Methicillin-Resistant Staphylococcus aureus Directly from Blood for the Diagnosis of Bloodstream Infections: A Mini-Review. Diagnostics. 2020; 10(10):830. https://doi.org/10.3390/diagnostics10100830

Chicago/Turabian Style

Buonomini, Anna R., Elisabetta Riva, Giovanni Di Bonaventura, and Giovanni Gherardi. 2020. "Rapid Detection of Methicillin-Resistant Staphylococcus aureus Directly from Blood for the Diagnosis of Bloodstream Infections: A Mini-Review" Diagnostics 10, no. 10: 830. https://doi.org/10.3390/diagnostics10100830

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