Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Data Analysis Methods
2.2. Ultrasonic-Based Elastography Phantoms
2.3. In Vivo Study: Healthy Volunteer Livers
Impact of Depth and Acquisition Protocol on Hepatic Segment Stiffness Measurements
2.4. Evaluation of Texture Feature Variability
3. Results
3.1. Robustness Evaluation Regarding Size and Type of Inclusions
3.2. Influence of Depth on Measured Stiffness
3.3. Robustness of Texture Features in Healthy Livers
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
GLNU | Gray Level Non-Uniformity for run |
HGRE | High Gray-level Run Emphasis |
LGRE | Low Gray-level Run Emphasis |
LRE | Long Run Emphasis |
LRHGE | Long Run High Gray-Level Emphasis |
LRLGE | Long Run Low Gray-level Emphasis |
RLNU | Run Length Non-Uniformity |
RP | Run Percentage |
SRE | Short Run Emphasis |
SRHGE | Short Run High Gray-level Emphasis |
SRLGE | Short Run Low Gray-level Emphasis |
HGZE | High Gray-level Zone Emphasis |
LGZE | Low Gray-level Zone Emphasis |
LZE | Long Zone Emphasis |
LZHGE | Long Zone High Gray-Level Emphasis |
SZE | Short Zone Emphasis |
SZHGE | Short Zone High Gray-Level Emphasis |
SZLGE | Short Zone Low Gray-Level Emphasis |
ZLNU | Zone Length Non-Uniformity |
ZP | Zone Percentage |
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Feature | Number of Segments with CV ≤ 15% B-Mode/Stiffness Map | Mean CV B-Mode/Stiffness Map |
---|---|---|
SRE | 8 | 2% |
RP | 8 | 3% |
Correlation | 8/5 | 3%/15% |
Entropy (GLCM) | 8 | 6% |
Entropy (histogram) | 8 | 6% |
RLNU | 8 | 7% |
SZE | 8 | 8% |
Homogeneity | 8/6 | 10%/11% |
LRE | 7 | 11% |
ZP | 6 | 11% |
GLNU | 5 | 15% |
Dissimilarity | 4 | 15% |
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Moalla, S.; Girot, C.; Franchi-Abella, S.; Ammari, S.; Balleyguier, C.; Lassau, N.; Pitre-Champagnat, S. Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors. Diagnostics 2020, 10, 811. https://doi.org/10.3390/diagnostics10100811
Moalla S, Girot C, Franchi-Abella S, Ammari S, Balleyguier C, Lassau N, Pitre-Champagnat S. Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors. Diagnostics. 2020; 10(10):811. https://doi.org/10.3390/diagnostics10100811
Chicago/Turabian StyleMoalla, Salma, Charly Girot, Stéphanie Franchi-Abella, Samy Ammari, Corinne Balleyguier, Nathalie Lassau, and Stéphanie Pitre-Champagnat. 2020. "Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors" Diagnostics 10, no. 10: 811. https://doi.org/10.3390/diagnostics10100811
APA StyleMoalla, S., Girot, C., Franchi-Abella, S., Ammari, S., Balleyguier, C., Lassau, N., & Pitre-Champagnat, S. (2020). Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors. Diagnostics, 10(10), 811. https://doi.org/10.3390/diagnostics10100811