Next Article in Journal
Invasive Pulmonary Aspergillosis in Patients with SARS-CoV-2 Infection: A Systematic Review of the Literature
Next Article in Special Issue
Predictors of Recurrence for T3a RCC: A Recurring Conundrum
Previous Article in Journal
Application of Hepatic Venous Pressure Gradient to Predict Prognosis in Cirrhotic Patients with a Low Model for End-stage Liver Disease Score
Previous Article in Special Issue
The Role of Imaging in Bladder Cancer Diagnosis and Staging
Open AccessReview

PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer

1
Department of Urology, The Oncology Institute “Prof Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania
2
Department of Urology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
3
MedFuture—Research Center for Advanced Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
4
Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
5
Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania
6
Surgery Department, The Oncology Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, Romania
7
Department of Surgery and Gynecological Oncology, the University of Medicine and Pharmacy “Iuliu Hatieganu”, 400337 Cluj-Napoca, Romania
8
Department of Urology, Clinical Municipal Hospital, 400139 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(10), 806; https://doi.org/10.3390/diagnostics10100806
Received: 3 August 2020 / Revised: 7 October 2020 / Accepted: 8 October 2020 / Published: 10 October 2020
Prostate cancer represents the most encountered urinary malignancy in males over 50 years old, and the second most diagnosed after lung cancer globally. Digital rectal examination and prostatic specific antigen were the long-time standard tools for diagnosis but with a significant risk of overdiagnosis and overtreatment. Magnetic resonance imaging recently entered the diagnosis process, but to this date, there is no specific biomarker that accurately indicates whether to proceed with the prostate biopsy. Research in this area has gone towards this direction, and recently, serum, urine, imagistic, tissue biomarkers, and Risk Calculators promise to help better diagnose and stratify prostate cancer. In order to eliminate the comorbidities that appear along with the diagnosis and treatment of this disease, there is a constant need to implement new diagnostic strategies. Important uro-oncology associations recommend the use of novel biomarkers in the grey area of prostate cancer, to better distinguish the next step in the diagnostic process. Although it is not that simple, they should be integrated according to the clinical policies, and it should be considered that statistical significance does not always equal clinical significance. In this review, we analyzed the contribution of prostate-specific antigen (PSA)-based biomarkers (PHI, PHID, 4Kscore, STHLM3), imagistic techniques (mp-MRI and mp-US), and combined tests in the early diagnosis process of localized prostate cancer. View Full-Text
Keywords: prostate cancer; biomarkers; screening; prostate-specific antigen; magnetic resonance imaging; prostate health index; 4Kscore; Stockholm 3 test; multiparametric ultrasound prostate cancer; biomarkers; screening; prostate-specific antigen; magnetic resonance imaging; prostate health index; 4Kscore; Stockholm 3 test; multiparametric ultrasound
Show Figures

Figure 1

MDPI and ACS Style

Munteanu, V.C.; Munteanu, R.A.; Gulei, D.; Schitcu, V.H.; Petrut, B.; Berindan Neagoe, I.; Achimas Cadariu, P.; Coman, I. PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer. Diagnostics 2020, 10, 806. https://doi.org/10.3390/diagnostics10100806

AMA Style

Munteanu VC, Munteanu RA, Gulei D, Schitcu VH, Petrut B, Berindan Neagoe I, Achimas Cadariu P, Coman I. PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer. Diagnostics. 2020; 10(10):806. https://doi.org/10.3390/diagnostics10100806

Chicago/Turabian Style

Munteanu, Vlad C.; Munteanu, Raluca A.; Gulei, Diana; Schitcu, Vlad H.; Petrut, Bogdan; Berindan Neagoe, Ioana; Achimas Cadariu, Patriciu; Coman, Ioan. 2020. "PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer" Diagnostics 10, no. 10: 806. https://doi.org/10.3390/diagnostics10100806

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop