Diagnostic Ability of Radiofrequency Ultrasound in Parkinson’s Disease Compared to Conventional Transcranial Sonography and Magnetic Resonance Imaging
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Control Group
2.2. Radiofrequency Transcranial Sonography (RF TCS)
- Amplitude parameters:
- Strain parameter—Lagrangian strain as module of the derivative of amplitudes of a mean repeated movement calculated along the ultrasound scanning line’s direction.
- Morphology parameter—frequency of high-end spectra peak (shortly–FreqHP) was calculated from the entire displacement signal length (6-s). FreqHP was estimated at the peak of the power spectra observed in the frequency range from 1.5 × FreqD to 22.5 Hz, where FreqD is the dominant frequency in displacement low-end spectra (from 0.67 to 2.00 Hz interval) supposedly caused by heart beats.
2.3. Conventional TCS (cTCS)
2.4. MRI Acquisition
2.5. Statistical Analysis
3. Results
3.1. Demographic Data and Single TCS and MRI Quantitative Measures
3.2. Models of Logistic Regression (LR) Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AUC | area under a curve |
FreqD | dominant frequency |
FreqHP | frequency of high-end spectra peak |
HC | healthy controls |
IQR | interquartile range |
LR | logistic regression |
MRI | magnetic resonance imaging |
PD | Parkinson’s disease |
RF | radiofrequency |
RMS | root mean square |
ROI | region of interest |
ROC | receiver operating characteristic |
RMS | root mean square |
SD | standard deviation |
SN | substantia nigra |
TCS | transcranial sonography |
UPDRS | the Unified Parkinson’s disease rating scale |
US | ultrasound |
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Variable | Mean ± Standard Deviation | p Value | |
---|---|---|---|
HC | PD | ||
All subjects | |||
Age, years | 68.5 ± 6.8 | 64.1 ± 10.1 | 0.17 |
Education, years | 15.2 ± 3.2 | 14.7 ± 2.9 | 0.61 |
Motor section of UPDRS | – | 33.2 ± 12.9 | – |
Subjects with repeatable waveforms in RF TCS recordings | |||
Age, years | 68.1 ± 6.8 | 62.9 ± 10.7 | 0.123 |
Education, years | 15.0 ± 3.2 | 14.9 ± 3.2 | 0.99 |
Motor section of UPDRS | – | 31.6 ± 10.7 | – |
SN dorsal width by MRI, mm | 4.29 ± 1.29 | 3.08 ± 1.77 | 0.007 |
SN ventral width by MRI, mm | 5.35 ± 1.31 | 4.05 ± 1.44 | 0.002 |
SN area by MRI, mm2 | 55.4 ± 7.9 | 33.1 ± 10.9 | <0.001 |
SN area by cTCS, mm2 | 10.8 ± 2.74 | 24.4 ± 7.49 | <0.001 |
Width of 3rd ventricle by MRI, mm | 6.19 ± 2.80 | 6.53 ± 1.98 | 0.70 |
Width of 3rd ventricle by cTCS, mm | 5.89 ± 1.89 | 6.58 ± 2.38 | 0.36 |
Parameter Estimate | β | Exp(β) | Exp(β) 95% CI | p Value |
---|---|---|---|---|
RFTCS 1st Model | ||||
RMS_exG_SD | −3.490 | 0.030 | [0.001, 0.684] | 0.028 |
FreqHP_Q3 | −4.392 | 0.012 | [0.000, 0.857] | 0.042 |
FreqHP_Q3 × RMS_exG_SD | 1.806 | 6.084 | [1.352, 27.37] | 0.019 |
Constant | 7.235 | 1387.2 | - | 0.112 |
RF TCS 2nd Model | ||||
RMS_exG_SD | −2.807 | 0.060 | [0.004, 0.917] | 0.043 |
FreqHP_Q3 | −3.627 | 0.027 | [0.001, 1.364] | 0.071 |
FreqHP_Q3 × RMS_exG_SD | 1.527 | 4.606 | [1.212, 17.50] | 0.025 |
Age | −0.120 | 0.887 | [0.811, 0.971] | 0.010 |
Constant | 12.873 | 3.898 × 105 | – | 0.012 |
RF TCS 3rd Model | ||||
RMS_exG_SD | −2.895 | 0.055 | [0.002, 1.433] | 0.081 |
FreqHP_Q3 | −3.915 | 0.020 | [0.000, 2.249] | 0.104 |
FreqHP_Q3 × RMS_exG_SD | 1.599 | 4.946 | [0.986, 24.806] | 0.052 |
Age | −0.135 | 0.873 | [0.791, 0.964] | 0.007 |
Relative energy in 4–6 Hz | 163.25 | 7.917 × 1070 | [0.000, 1.083 × 10180] | 0.203 |
Constant | 13.448 | 6.923 × 105 | – | 0.018 |
cTCS 1st Model | ||||
TCS_SN_area | 0.731 | 2.076 | [1.319, 3.267] | 0.002 |
Constant | −11.868 | 0.000 | – | 0.001 |
cTCS 2nd Model | ||||
TCS_SN_area | 0.808 | 2.243 | [1.239, 4.063] | 0.008 |
Age | −0.119 | 0.888 | [0.694, 1.136] | 0.345 |
Constant | −5.084 | 0.006 | – | 0.463 |
MRI1st Model | ||||
MRI_SN_area | −0.225 | 0.798 | [0.706, 0.902] | <0.001 |
Constant | 9.633 | 1.526 × 104 | – | 0.001 |
MRI 2nd Model | ||||
MRI_SN_area | −0.264 | 0.768 | [0.652, 0.905] | 0.002 |
Age | −0.202 | 0.817 | [0.680, 0.981] | 0.031 |
Constant | 23.973 | 2.578 × 1010 | – | 0.006 |
Model | AUC, % | 95% CI | p Value | Cut-Off, % | Sensitivity, % | Specificity, % | Overall Correct Classification, % |
---|---|---|---|---|---|---|---|
RF TCS 1st | 80.9 | [69.1, 92.7] | <0.001 | 29.9 | 85.0 | 69.0 | 75.5 |
RF TCS 2nd | 86.2 | [74.9, 97.6] | <0.001 | 44.6 | 80.0 | 86.2 | 83.7 |
RF TCS 3rd | 88.3 | [78.6, 97.9] | <0.001 | 42.7 | 80.0 | 86.2 | 83.7 |
cTCS 1st | 98.2 | [94.9, 100.0] | <0.001 | 77.7 | 90.0 | 100.0 | 95.9 |
cTCS 2nd | 98.7 | [96.5, 100.0] | <0.001 | 70.8 | 90.0 | 100.0 | 95.9 |
MRI 1st | 94.1 | [86.5, 100.0] | 0.039 | 54.1 | 90.0 | 96.6 | 93.9 |
MRI 2nd | 97.8 | [94.3, 100.0] | 0.018 | 43.3 | 95.0 | 96.6 | 95.9 |
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Baranauskas, M.; Jurkonis, R.; Lukoševičius, A.; Matijošaitis, V.; Gleiznienė, R.; Rastenytė, D. Diagnostic Ability of Radiofrequency Ultrasound in Parkinson’s Disease Compared to Conventional Transcranial Sonography and Magnetic Resonance Imaging. Diagnostics 2020, 10, 778. https://doi.org/10.3390/diagnostics10100778
Baranauskas M, Jurkonis R, Lukoševičius A, Matijošaitis V, Gleiznienė R, Rastenytė D. Diagnostic Ability of Radiofrequency Ultrasound in Parkinson’s Disease Compared to Conventional Transcranial Sonography and Magnetic Resonance Imaging. Diagnostics. 2020; 10(10):778. https://doi.org/10.3390/diagnostics10100778
Chicago/Turabian StyleBaranauskas, Mindaugas, Rytis Jurkonis, Arūnas Lukoševičius, Vaidas Matijošaitis, Rymantė Gleiznienė, and Daiva Rastenytė. 2020. "Diagnostic Ability of Radiofrequency Ultrasound in Parkinson’s Disease Compared to Conventional Transcranial Sonography and Magnetic Resonance Imaging" Diagnostics 10, no. 10: 778. https://doi.org/10.3390/diagnostics10100778