Next Article in Journal
Successive Paradigm Shifts in the Bacterial Cell Cycle and Related Subjects
Next Article in Special Issue
Plausible Emergence of Autocatalytic Cycles under Prebiotic Conditions
Previous Article in Journal / Special Issue
The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code
Open AccessReview

How Prebiotic Chemistry and Early Life Chose Phosphate

1
UMR5247, CNRS—University of Montpellier—ENSCM, Place E. Bataillon, 34095 Montpellier CEDEX 5, France
2
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK
*
Author to whom correspondence should be addressed.
Received: 5 February 2019 / Revised: 23 February 2019 / Accepted: 25 February 2019 / Published: 3 March 2019
The very specific thermodynamic instability and kinetic stability of phosphate esters and anhydrides impart them invaluable properties in living organisms in which highly efficient enzyme catalysts compensate for their low intrinsic reactivity. Considering their role in protein biosynthesis, these properties raise a paradox about early stages: How could these species be selected in the absence of enzymes? This review is aimed at demonstrating that considering mixed anhydrides or other species more reactive than esters and anhydrides can help in solving the paradox. The consequences of this approach for chemical evolution and early stages of life are analysed. View Full-Text
Keywords: phosphoryl transfer; metabolism; energy currency; mixed anhydride phosphoryl transfer; metabolism; energy currency; mixed anhydride
Show Figures

Figure 1

MDPI and ACS Style

Liu, Z.; Rossi, J.-C.; Pascal, R. How Prebiotic Chemistry and Early Life Chose Phosphate. Life 2019, 9, 26.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop