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Life 2015, 5(2), 1454-1471;

Acetate Metabolism in Anaerobes from the Domain Archaea

Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
Academic Editors: Hans-Peter Klenk, Michael W. W. Adams and Roger A. Garrett
Received: 16 April 2015 / Accepted: 1 June 2015 / Published: 9 June 2015
(This article belongs to the Special Issue Archaea: Evolution, Physiology, and Molecular Biology)
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Acetate and acetyl-CoA play fundamental roles in all of biology, including anaerobic prokaryotes from the domains Bacteria and Archaea, which compose an estimated quarter of all living protoplasm in Earth’s biosphere. Anaerobes from the domain Archaea contribute to the global carbon cycle by metabolizing acetate as a growth substrate or product. They are components of anaerobic microbial food chains converting complex organic matter to methane, and many fix CO2 into cell material via synthesis of acetyl-CoA. They are found in a diversity of ecological habitats ranging from the digestive tracts of insects to deep-sea hydrothermal vents, and synthesize a plethora of novel enzymes with biotechnological potential. Ecological investigations suggest that still more acetate-metabolizing species with novel properties await discovery. View Full-Text
Keywords: methanogenesis; fermentation; respiration; Methanosarcina; Pyrococcus; carbon monoxide methanogenesis; fermentation; respiration; Methanosarcina; Pyrococcus; carbon monoxide

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Ferry, J.G. Acetate Metabolism in Anaerobes from the Domain Archaea. Life 2015, 5, 1454-1471.

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