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Volume 16
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10.3390/life16071081
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Effects of Olive Leaf Extract on Anxiety Symptoms and Metainflammation in Women with Excess Weight: A Randomized Double-Blind Placebo-Controlled Pilot Trial

by
Mario Hernández-Garibay
1,
David Fernández-Quezada
1,*,
Joaquín García-Estrada
1,
Ulises de la Cruz-Mosso
1,
Rosa Yaveth Ruvalcaba-Delgadillo
2,
Rocio Elizabeth González-Castañeda
1 and
Sonia Luquin
1,*
1
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Sierra Mojada 950, Guadalajara 44340, Mexico
2
Laboratorio de Microscopia de Alta Resolución, Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Sierra Mojada 950, Guadalajara 44340, Mexico
*
Authors to whom correspondence should be addressed.
Life 2026, 16(7), 1081; https://doi.org/10.3390/life16071081
Submission received: 14 May 2026 / Revised: 23 June 2026 / Accepted: 26 June 2026 / Published: 28 June 2026
(This article belongs to the Section Medical Research)
Versions Notes

Abstract

Anxiety symptomatology and excess weight are associated with chronic low-grade inflammation. Olive leaf extract (OLE) contains polyphenols with antioxidant and anti-inflammatory properties that have shown anxiolytic-like effects in experimental models; however, evidence in humans remains limited. This randomized double-blind placebo-controlled pilot trial evaluated the effects of OLE supplementation on anxiety symptomatology, inflammatory markers, and metabolic parameters in women with excess weight and mild to moderate anxiety symptoms. Participants received OLE (750 mg/day) or placebo for 12 weeks. Anxiety symptomatology was assessed using HAM-A, BAI, and STAI, while inflammatory and metabolic parameters were evaluated at baseline and post-intervention. Since the expected sample size was not achieved, our results are preliminary. No effect was observed from OLE supplementation. However, some differences within groups can direct future researchers interested in evaluating these parameters. OLE supplementation correlated with a particular reduction phenotype in anxious symptomatology (HAM-A, BAI and STAI-Trait) with inflammatory (hs-CRP) and metabolic parameters (c-HDL) that may open the possibility of an anti-inflammatory effect. In contrast, the observations in the Pb group seemed more associated with a pro-inflammatory state and a placebo effect related to somatic symptoms of anxiety. These preliminary observations need to be confirmed with larger randomized clinical trials that may help clarify these results and the possible underlying mechanisms.
Keywords: olive leaf extract; metainflammation; overweight; obesity; inflammation; anxiety; anxious symptomatology olive leaf extract; metainflammation; overweight; obesity; inflammation; anxiety; anxious symptomatology

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MDPI and ACS Style

Hernández-Garibay, M.; Fernández-Quezada, D.; García-Estrada, J.; de la Cruz-Mosso, U.; Ruvalcaba-Delgadillo, R.Y.; González-Castañeda, R.E.; Luquin, S. Effects of Olive Leaf Extract on Anxiety Symptoms and Metainflammation in Women with Excess Weight: A Randomized Double-Blind Placebo-Controlled Pilot Trial. Life 2026, 16, 1081. https://doi.org/10.3390/life16071081

AMA Style

Hernández-Garibay M, Fernández-Quezada D, García-Estrada J, de la Cruz-Mosso U, Ruvalcaba-Delgadillo RY, González-Castañeda RE, Luquin S. Effects of Olive Leaf Extract on Anxiety Symptoms and Metainflammation in Women with Excess Weight: A Randomized Double-Blind Placebo-Controlled Pilot Trial. Life. 2026; 16(7):1081. https://doi.org/10.3390/life16071081

Chicago/Turabian Style

Hernández-Garibay, Mario, David Fernández-Quezada, Joaquín García-Estrada, Ulises de la Cruz-Mosso, Rosa Yaveth Ruvalcaba-Delgadillo, Rocio Elizabeth González-Castañeda, and Sonia Luquin. 2026. "Effects of Olive Leaf Extract on Anxiety Symptoms and Metainflammation in Women with Excess Weight: A Randomized Double-Blind Placebo-Controlled Pilot Trial" Life 16, no. 7: 1081. https://doi.org/10.3390/life16071081

APA Style

Hernández-Garibay, M., Fernández-Quezada, D., García-Estrada, J., de la Cruz-Mosso, U., Ruvalcaba-Delgadillo, R. Y., González-Castañeda, R. E., & Luquin, S. (2026). Effects of Olive Leaf Extract on Anxiety Symptoms and Metainflammation in Women with Excess Weight: A Randomized Double-Blind Placebo-Controlled Pilot Trial. Life, 16(7), 1081. https://doi.org/10.3390/life16071081

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