Next Article in Journal
Allium kazim-kosei, a New Species (A. sect. Codonoprasum, Amaryllidaceae) from Central Anatolia (Türkiye)
Previous Article in Journal
Machine Learning-Based Identification of Candidate Serum miRNA Features for Pan-Cancer and Cancer Type Classification
Previous Article in Special Issue
Integrated Bone and Ligamentous Reconstruction of the Distal Radius After Oncologic Resection: Proximal Fibular Autograft Combined with Distal Oblique Bundle Reconstruction
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 16
Issue 5
10.3390/life16050851
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study

by
Sebastian Dominiak
1,
Marzena Dominiak
1,
Jakub Hadzik
1,
Michał Ciszyński
1,
Marta Kepinska
2,
Mirosław Banasik
3,
Aleksandra Piotrowska
4,
Piotr Dzięgiel
4,
Tomasz Gedrange
1,
Alicja Baranowska
1 and
Paweł Kubasiewicz-Ross
1,*
1
Oral Surgery Department, Wroclaw Medical University, Krakowska 26 St., 50-425 Wroclaw, Poland
2
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland
3
Department of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
4
Department of Human Morphology and Embryology, Wroclaw Medical University, Chałubińskiego 6a St., 50-368 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Life 2026, 16(5), 851; https://doi.org/10.3390/life16050851 (registering DOI)
Submission received: 24 April 2026 / Revised: 15 May 2026 / Accepted: 18 May 2026 / Published: 20 May 2026
(This article belongs to the Special Issue Reconstruction of Bone Defects)
Review Reports Versions Notes

Abstract

(1) Background: The role of baseline humoral immunization in bone regeneration remains unclear. This study assessed the relationship between baseline serological immunization, graft type, photobiomodulation (PBM), and histological outcomes after maxillary sinus floor augmentation. (2) Methods: This exploratory secondary analysis included 20 adults undergoing lateral maxillary sinus lifting. Patients were allocated according to graft type (allogeneic or xenogeneic) and postoperative protocol (with or without adjunctive PBM). Before surgery, serum samples were analyzed for anti-HLA class I, anti-HLA class II, and anti-MICA antibodies. After approximately 6 months, bone core biopsies were collected. Histological evaluation focused on inflammatory cell infiltrates (ICI). (3) Results: Baseline antibody positivity was detected in 35.0% of patients for anti-HLA class I, 55.0% for anti-HLA class II, and 45.0% for anti-MICA. Histological findings were generally favorable. ICI scores were low, with 65.0% of samples scoring 0 and 35.0% scoring 1. A nominal positive correlation was observed between anti-HLA class I NBG ratio and ICI; however, this finding did not remain statistically significant after correction for multiple comparisons. Exploratory PBM subgroup estimates were directionally different but were based on very small subgroups and should not be interpreted as evidence of effect modification. (4) Conclusions: The findings suggest a possible hypothesis-generating link between baseline humoral sensitization and mild local inflammatory infiltrates, which requires validation in larger, prospectively powered studies with predefined histological and immunological endpoints.
Keywords: maxillary sinus floor augmentation; bone regeneration; anti-HLA antibodies; anti-MICA antibodies; photobiomodulation; allograft; xenograft; histology; osteoimmunology maxillary sinus floor augmentation; bone regeneration; anti-HLA antibodies; anti-MICA antibodies; photobiomodulation; allograft; xenograft; histology; osteoimmunology

Share and Cite

MDPI and ACS Style

Dominiak, S.; Dominiak, M.; Hadzik, J.; Ciszyński, M.; Kepinska, M.; Banasik, M.; Piotrowska, A.; Dzięgiel, P.; Gedrange, T.; Baranowska, A.; et al. Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study. Life 2026, 16, 851. https://doi.org/10.3390/life16050851

AMA Style

Dominiak S, Dominiak M, Hadzik J, Ciszyński M, Kepinska M, Banasik M, Piotrowska A, Dzięgiel P, Gedrange T, Baranowska A, et al. Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study. Life. 2026; 16(5):851. https://doi.org/10.3390/life16050851

Chicago/Turabian Style

Dominiak, Sebastian, Marzena Dominiak, Jakub Hadzik, Michał Ciszyński, Marta Kepinska, Mirosław Banasik, Aleksandra Piotrowska, Piotr Dzięgiel, Tomasz Gedrange, Alicja Baranowska, and et al. 2026. "Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study" Life 16, no. 5: 851. https://doi.org/10.3390/life16050851

APA Style

Dominiak, S., Dominiak, M., Hadzik, J., Ciszyński, M., Kepinska, M., Banasik, M., Piotrowska, A., Dzięgiel, P., Gedrange, T., Baranowska, A., & Kubasiewicz-Ross, P. (2026). Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study. Life, 16(5), 851. https://doi.org/10.3390/life16050851

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop