High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Primary Therapy | Salvage Therapy | |
---|---|---|
No. of patients (N) | 31 | 12 |
Median age (IQR) | 70 (64–74) | 71 (67–73) |
Median cc prostate volume (IQR) | 33 (24–50) | 22 (16–32) |
Median ng/mL PSA (IQR) | 6.2 (4.3–9.0) | 4.9 (4.8–8.8) |
Median ng/mL/cc PSA density (IQR) | 0.19 (0.09–0.29) | 0.22 (0.15–0.51) |
Clinical stage (%) | ||
T1c | 23 (74.2) | 10 (83.3) |
T2a | 1 (3.2) | 0 (0.0) |
T2b | 2 (6.5) | 1 (8.3) |
T2c | 5 (16.1) | 1 (9.3) |
ISUP grade group (%) | ||
1 | 2 (6.5) | 2 (16.6) |
2 | 11 (35.5) | 2 (16.6) |
3 | 7 (22.6) | 2 (16.6) |
4 | 6 (19.4) | 0 (0.0) |
5 | 5 (16.1) | 6 (50.0) |
Entry biopsy | ||
Median no. of cores taken (IQR) | 12 (12–12) | 12 (12–12) |
Median pos cores (any Ca) (IQR) | 4 (2–6) | 4 (2–7) |
Median max Ca core % (IQR) | 50 (20–65) | 43 (24–65) |
Amount of bilateral Ca on biopsy (%) | 11 (35.5) | 5 (41.7) |
NCCN risk group (%) | ||
Low | 2 (6.5) | 2 (16.6) |
Intermediate favorable | 8 (25.8) | 2 (16.6) |
Intermediate unfavorable | 10 (32.2) | 1 (8.3) |
High | 11 (35.5) | 7 (58.3) |
Prior therapy (%) | ||
Radiation | 0 (0.0) | 12 (100.0) |
Hormonal therapy | 0 (0.0) | 1 (8.3) |
Median CCI (IQR) | 7 (5–8) | 5 (4–6) |
Median BMI (IQR) | 27 (22–31) | 33 (30–34) |
Prior abdominal surgery (%) | 9 (29.0) | 2 (16.6) |
Primary Therapy | Salvage Therapy | |
---|---|---|
Median follow-up period, in months (IQR) | 23 (15–34) | 25 (9–39) |
Median PSA nadir (IQR) | 0.16 (0.06–2.96) | 0.12 (0.01–0.71) |
Median time to PSA nadir, in months (IQR) | 6 (3–9) | 3 (3–9) |
Median % PSA decrease (IQR) | 96 (55–99) | 98 (93–99) |
Local recurrence (%) | 5 (16.1) | 2 (16.6) |
Post-HIFU treatment (%) | ||
Radiation | 2 (6.5) | 0 (0) |
Hormonal | 1 (3.2) | 2 (16.6) |
HIFU | 1 (3.2) | 0 (0) |
Radical prostatectomy | 1 (3.2) | 0 (0) |
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Patel, S.; Antar, A.; Alrabaa, A.; Saffati, G.; Fleming, B.; Srikishen, N.; Slawin, J.; Taylor, J.; Jones, J. High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting. Life 2025, 15, 17. https://doi.org/10.3390/life15010017
Patel S, Antar A, Alrabaa A, Saffati G, Fleming B, Srikishen N, Slawin J, Taylor J, Jones J. High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting. Life. 2025; 15(1):17. https://doi.org/10.3390/life15010017
Chicago/Turabian StylePatel, Sagar, Ali Antar, Aly Alrabaa, Gal Saffati, Broderick Fleming, Neel Srikishen, Jeremy Slawin, Jennifer Taylor, and Jeffrey Jones. 2025. "High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting" Life 15, no. 1: 17. https://doi.org/10.3390/life15010017
APA StylePatel, S., Antar, A., Alrabaa, A., Saffati, G., Fleming, B., Srikishen, N., Slawin, J., Taylor, J., & Jones, J. (2025). High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting. Life, 15(1), 17. https://doi.org/10.3390/life15010017