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Volume 14
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10.3390/life14080991
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Review

Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment

by
Marina Mattar
1,†,
Florence Umutoni
2,†,
Marwa A. Hassan
1,
M. Wambui Wamburu
3,
Reagan Turner
4,
James S. Patton
2,
Xin Chen
5 and
Wei Lei
1,2,*
1
Department of Pharmaceutical and Administrative Sciences, Presbyterian College School of Pharmacy, Clinton, SC 29325, USA
2
Department of Pharmaceutical and Graduate Life Sciences, College of Health Sciences, Nursing, and Pharmacy, Manchester University, Fort Wayne, IN 46845, USA
3
Department of Pharmacy Practice, College of Health Sciences, Nursing, and Pharmacy, Manchester University, Fort Wayne, IN 46845, USA
4
Department of Biology, Presbyterian College, Clinton, SC 29325, USA
5
Department of Pharmaceutical and Clinical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27506, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the paper.
Life 2024, 14(8), 991; https://doi.org/10.3390/life14080991
Submission received: 20 June 2024 / Revised: 29 July 2024 / Accepted: 7 August 2024 / Published: 9 August 2024
(This article belongs to the Special Issue Conservative Management of Chronic Disease)
Versions Notes

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a major long-lasting side effect of some chemotherapy drugs, which threatens cancer survival rate. CIPN mostly affects sensory neurons and occasionally motor neurons, causing numbness, tingling, discomfort, and burning pain in the upper and lower extremities. The pathophysiology of CIPN is not completely understood; however, it is believed that chemotherapies induce peripheral neuropathy via directly damaging mitochondria, impairing the function of ion channels, triggering immunological mechanisms, and disrupting microtubules. The treatment of CIPN is a medical challenge, and there are no approved pharmacological options. Currently, duloxetine and other antidepressants, antioxidant, anti-inflammatory, and ion-channel targeted therapies are commonly used in clinics to relieve the symptoms of CIPN. Several other types of drugs, such as cannabinoids, sigma−1 receptor antagonists, and nicotinamides ribose, are being evaluated in preclinical and clinical studies. This paper summarizes the information related to the physiology of CIPN and medicines that could be used for treating this condition.
Keywords: chemotherapy-induced peripheral neuropathy; pathophysiology; duloxetine; cannabinoid; pain chemotherapy-induced peripheral neuropathy; pathophysiology; duloxetine; cannabinoid; pain

Share and Cite

MDPI and ACS Style

Mattar, M.; Umutoni, F.; Hassan, M.A.; Wamburu, M.W.; Turner, R.; Patton, J.S.; Chen, X.; Lei, W. Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment. Life 2024, 14, 991. https://doi.org/10.3390/life14080991

AMA Style

Mattar M, Umutoni F, Hassan MA, Wamburu MW, Turner R, Patton JS, Chen X, Lei W. Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment. Life. 2024; 14(8):991. https://doi.org/10.3390/life14080991

Chicago/Turabian Style

Mattar, Marina, Florence Umutoni, Marwa A. Hassan, M. Wambui Wamburu, Reagan Turner, James S. Patton, Xin Chen, and Wei Lei. 2024. "Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment" Life 14, no. 8: 991. https://doi.org/10.3390/life14080991

APA Style

Mattar, M., Umutoni, F., Hassan, M. A., Wamburu, M. W., Turner, R., Patton, J. S., Chen, X., & Lei, W. (2024). Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment. Life, 14(8), 991. https://doi.org/10.3390/life14080991

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