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Review

Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration

by
Andreea Dana Moraru
1,2,
Ciprian Danielescu
1,2,*,†,
Raluca Eugenia Iorga
1,2,*,
Radu Lucian Moraru
3,
Mihail Zemba
4,† and
Daniel Constantin Branisteanu
1,5
1
Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iași, Romania
2
Department of Ophthalmology, ‘N. Oblu’ Clinical Hospital, 700309 Iași, Romania
3
‘Transmed Expert’ Medical Center, 700011 Iași, Romania
4
Department of Ophthalmology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania
5
Department of Ophthalmology, Railway Clinical Hospital, 700506 Iași, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2024, 14(10), 1220; https://doi.org/10.3390/life14101220
Submission received: 28 June 2024 / Revised: 9 September 2024 / Accepted: 23 September 2024 / Published: 24 September 2024
(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 2nd Edition)
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Abstract

Neovascular age-related macular degeneration is a progressive, blinding macular disease that has become a burden both in healthcare systems and the global economy. The vascular endothelial growth factor (VEGF) is the main agent involved in the pathogenic process of the disease. The main goal of the age-related macular degeneration treatment is to maintain and improve visual acuity by injecting intravitreal anti-VEGF agents in either a reactive or proactive manner. Subretinal and intraretinal fluids are the main biomarkers that should be considered when managing the frequency of the therapy. This review discusses both functional and morphological treatment criteria according to current recommendations as opposed to real-life situations encountered during day-to-day clinical practice and highlights situations in which the benefits of continuing therapy are arguable in terms of improving patients’ quality of life. Optimizing the treatment regimen represents an important aim of current clinical ophthalmological practice, as age-related macular degeneration patients usually have a long follow-up period.
Keywords: age-related macular degeneration; anti-VEGF therapy; treat and extend; intraretinal fluid; subretinal fluid age-related macular degeneration; anti-VEGF therapy; treat and extend; intraretinal fluid; subretinal fluid

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MDPI and ACS Style

Moraru, A.D.; Danielescu, C.; Iorga, R.E.; Moraru, R.L.; Zemba, M.; Branisteanu, D.C. Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration. Life 2024, 14, 1220. https://doi.org/10.3390/life14101220

AMA Style

Moraru AD, Danielescu C, Iorga RE, Moraru RL, Zemba M, Branisteanu DC. Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration. Life. 2024; 14(10):1220. https://doi.org/10.3390/life14101220

Chicago/Turabian Style

Moraru, Andreea Dana, Ciprian Danielescu, Raluca Eugenia Iorga, Radu Lucian Moraru, Mihail Zemba, and Daniel Constantin Branisteanu. 2024. "Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration" Life 14, no. 10: 1220. https://doi.org/10.3390/life14101220

APA Style

Moraru, A. D., Danielescu, C., Iorga, R. E., Moraru, R. L., Zemba, M., & Branisteanu, D. C. (2024). Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration. Life, 14(10), 1220. https://doi.org/10.3390/life14101220

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