COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review
Abstract
:1. Introduction
1.1. Background Information on COVID-19 and Its Impact in Romania
1.2. Importance of Laboratory Findings in Understanding and Managing the Disease and Purpose of the Study
2. Materials and Methods
2.1. Study Design, Sample Selection and Data Collection
2.2. Limitations
3. Results
3.1. PCR Testing
3.2. C-Reactive Protein (CRP)
3.3. Cytokines and Other Proinflammatory Markers
3.4. Lactate Dehydrogenase (LDH)
3.5. Creatine-Kinase (CK) and Its Isoforms
3.6. Troponins (TN’S) and Other Cardiac Markers
3.7. Ferritin (FER) and Other Iron Markers
3.8. High- and Low-Density Lipoprotein Cholesterol Markers (HDL and LDL), Triglycerides
3.9. Transaminase Levels and Other Hepatic Markers
3.10. Vitamin D (25-OHD)
3.11. Procalcitonin (PCT)
3.12. D-Dimers
3.13. Fibrinogen and Other Clotting Markers
3.14. Blood Urea Nitrogen (BUN) and Other Renal Markers
3.15. Complete Blood Counts (CBC) and Other Blood Test Markers
3.16. Microbiological Cultures and Assessments
3.17. Other Markers: Thyroid, Antibodies and Ablumin
4. Discussions
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Assessment | General Role | Most Frequent Modification | Studied Populations | Predictive Ability (Ref.) | Clinical Associations (Ref.) |
---|---|---|---|---|---|
RT-PCR | Early detection; diagnosis | Positive | General | - | - |
Antigen levels—IgM, IgG | Diagnosis; post-vaccination monitoring | Elevated | General | - | - |
CRP | Disease severity assessment; monitoring progression; therapeutic guidance | Elevated | Adults, children, infants, elders, Roma | Yes, even more so in Roma [53,54,58,59,60,61,62,70] | Diabetes [48,94] Antiphospholipid syndrome [47] Hypertension [27] Cardiac dysfunction [46,73,93] Overweight/metabolic syndrome [27,54,93] Lung involvement [50,57] PIMS [83] Chronic Spontaneous Urticaria Exacerbation [42] Pneumothorax/pneumomediastinum [31,72] Liver failure [44] Multiple organ dysfunction [60] |
LDH | Disease severity assessment; monitoring progression; therapeutic guidance | Elevated | General | Yes [57,58,61] | Lung involvement [57] Chronic Spontaneous Urticaria Exacerbation [42] |
FER | Disease severity assessment | Elevated | Adults, children, elders | Yes [58,60,70] | Pneumothorax/pneumomediastinum [31,72] |
HDL | Disease severity assessment | Elevated | Adults, children, elders | Yes [46,58,93] | - |
Vitamin D | Disease severity assessment | Decreased | Adults, children, elders | Yes [57,58,102,103] No [55] | More comorbidities [29,101] Lung involvement [57] |
PCT | Disease severity assessment; evaluation of complications | Elevated | Adults | Yes [36] | Diabetes [48] Co-/supra-infections [40,115,116] |
D-dimers | Disease severity assessment; monitoring progression; evaluation of complications | Elevated | Adults, elders | Yes [26,36,60,105] | Hypertension, overweight [27] Cardiac dysfunction [73] Liver failure [44] PIMS [83] Pneumothorax/pneumomediastinum [31,72] Liver failure [44] Multiple organ dysfunction [60] |
BUN | Disease severity assessment | Elevated | Adults | - | - |
Neutrophils | Disease severity assessment; monitoring progression | Increased | General | - | - |
Lymphocytes | Disease severity assessment; monitoring progression | Decreased | General | - | - |
Platelets | Disease severity assessment; monitoring progression | Decreased | General | - | - |
NLR | Disease severity assessment; monitoring progression; therapeutic guidance | Increased | General | Yes [26,29,36,48,111] | Lung involvement [50] |
ESR | Evaluation of complications | Increased | Children | - | - |
Cytokines—IL-1, IL-6, IL-8, IL-1β, IFN-γ, TNF-α, TGF- β | Monitoring progression; therapeutic guidance | Elevated | Adults, children, elders, Roma, pregnant and lactating women | Yes; IL-6, especially in Roma [36,53,59,60] | IL-6: hypertension, overweight [27,54]; lung involvement [50,72]; cardiac dysfunction [73]; multiple organ dysfunction [74]; liver failure [44] IL1β, IL-8: bacterial infection [49] |
Tn’s | Monitoring progression | Elevated | Adults | Yes [33] No [21,86] | Cardiac dysfunction [33] |
BNP | Monitoring progression | Elevated | Adults, children | Yes [33] No [21,86] | Cardiac dysfunction [33] |
AST and ALT | Therapeutic guidance | Elevated | Remdesivir side-effects in children | - | |
Fibrinogen | Evaluation of complications | Elevated | Adults, children | Yes [33,41,62] No [29,61,79] | PIMS [41] Cardiac dysfunction [33] |
Creatinine | Evaluation of complications | Elevated | Children, elders, Roma | Yes [53,59,62,83] | PIMS [83] Renal dysfunction [41,59] |
Albumin | Evaluation of complications | Decreased | Children | - | - |
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Musat, O.; Sorop, V.B.; Sorop, M.I.; Lazar, V.; Marti, D.T.; Susan, M.; Avram, C.R.; Oprisoni, A.; Vulcanescu, D.D.; Horhat, F.G.; et al. COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review. Life 2023, 13, 1837. https://doi.org/10.3390/life13091837
Musat O, Sorop VB, Sorop MI, Lazar V, Marti DT, Susan M, Avram CR, Oprisoni A, Vulcanescu DD, Horhat FG, et al. COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review. Life. 2023; 13(9):1837. https://doi.org/10.3390/life13091837
Chicago/Turabian StyleMusat, Ovidiu, Virgiliu Bogdan Sorop, Madalina Ioana Sorop, Viorica Lazar, Daniela Teodora Marti, Monica Susan, Cecilia Roberta Avram, Andrada Oprisoni, Dan Dumitru Vulcanescu, Florin George Horhat, and et al. 2023. "COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review" Life 13, no. 9: 1837. https://doi.org/10.3390/life13091837
APA StyleMusat, O., Sorop, V. B., Sorop, M. I., Lazar, V., Marti, D. T., Susan, M., Avram, C. R., Oprisoni, A., Vulcanescu, D. D., Horhat, F. G., Bagiu, I. C., Horhat, D. I., & Diaconu, M. M. (2023). COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review. Life, 13(9), 1837. https://doi.org/10.3390/life13091837