Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Dataset and Study Design
2.2. Image Acquisition and Measurements
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Case Group (n = 86) | Control Group (n = 1071) | p-Value | |
---|---|---|---|
Follow-up time (Years) (Median [IQR]) | 2.1 [1.9–3.4] | 5.5 [5.4–5.7] | N/A |
Sex (No.) | 0.22 | ||
Male | 51 | 712 | |
Female | 35 | 359 | |
Age (Years) (Median [IQR]) | 61 [54–69] | 56 [48–64] | <0.01 |
TSH (IU/mL) (Median [IQR]) | 2.80 [2.23–3.63] | 1.30 [0.87–1.84] | <0.01 |
T4 (ng/dL) (Median [IQR]) | 1.08 [0.92–1.23] | 1.12 [1.12–1.26] | <0.01 |
CT density (HU) (Median [IQR]) | 89.8 [74.3–99.8] | 81.7 [73.5–90.0] | <0.01 |
Volume (mL) (Median [IQR]) | 13.0 [10.1–16.4] | 15.3 [11.9–19.2] | <0.01 |
Non-Adjusted Odds Ratio (95%CI) | p-Value | Multivariable-Adjusted Odds Ratio * (95% CI) | p-Value | |
---|---|---|---|---|
CT density (+10 HU) | 1.40 (1.16–1.67) | <0.01 | 1.44 (1.17–1.77) | <0.01 |
Volume (−3 mL) | 1.26 (1.10–1.45) | <0.01 | 1.33 (1.11–1.59) | <0.01 |
Baseline | End of Follow-Up * | p-Value | Changes | |
---|---|---|---|---|
TSH | ||||
Case group | 2.80 [2.23–3.63] | 5.21 [4.89–5.76] | ** | 2.53 [1.80–3.25] |
Control group | 1.30 [0.87–1.84] | 1.32 [0.92–1.85] | ** | 0.02 [−0.27–0.35] |
T4 | ||||
Case group | 1.12 [1.00–1.26] | 1.09 [0.99–1.21] | <0.01 | −0.03 [−0.17–0.11] |
Control group | 1.08 [0.92–1.23] | 1.05 [0.87–1.17] | 0.04 | −0.04 [−0.23–0.11] |
CT density | ||||
Case group | 89.8 [74.3–99.8] | 77.5 [66.0–90.7] | <0.01 | −8.4 [−17.1–−1.1] |
Control group | 81.7 [73.5–90.0] | 78.3 [71.0–86.5] | <0.01 | −2.9 [−8.5–1.8] |
Volume | ||||
Case group | 13.0 [10.1–16.4] | 13.1 [9.9–16.3] | 0.23 | −0.1 [−1.9–1.2] |
Control group | 15.3 [11.9–19.2] | 15.1 [12.0–18.9] | 0.29 | −0.1 [−1.4–1.2] |
Coefficient | Standard Error | 95%CI | p-Value | |
---|---|---|---|---|
Constant | 0.124 | 0.034 | 0.058–0.190 | <0.01 |
Changes in CT (HU) | −0.022 | 0.003 | −0.029–−0.015 | <0.01 |
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Kikuchi, T.; Hanaoka, S.; Nakao, T.; Nomura, Y.; Yoshikawa, T.; Alam, M.A.; Mori, H.; Hayashi, N. Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study. Life 2023, 13, 2303. https://doi.org/10.3390/life13122303
Kikuchi T, Hanaoka S, Nakao T, Nomura Y, Yoshikawa T, Alam MA, Mori H, Hayashi N. Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study. Life. 2023; 13(12):2303. https://doi.org/10.3390/life13122303
Chicago/Turabian StyleKikuchi, Tomohiro, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Md Ashraful Alam, Harushi Mori, and Naoto Hayashi. 2023. "Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study" Life 13, no. 12: 2303. https://doi.org/10.3390/life13122303