Next Article in Journal
In Situ Monitoring and Quantitative Determination of R27 Plasmid Conjugation
Previous Article in Journal
Transcriptome Analysis of Sugarcane Young Leaves and Protoplasts after Enzymatic Digestion
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 12
Issue 8
10.3390/life12081211
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling

by
Wei Wen
,
Chenchen Sun
,
Zhanglin Chen
,
Dong Yang
,
Zuoqiong Zhou
*,
Xiyang Peng
* and
Changfa Tang
*
Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, College of Physical Education, Hunan Normal University, Changsha 410012, China
*
Authors to whom correspondence should be addressed.
Life 2022, 12(8), 1211; https://doi.org/10.3390/life12081211
Submission received: 19 July 2022 / Revised: 4 August 2022 / Accepted: 6 August 2022 / Published: 10 August 2022
(This article belongs to the Section Physiology and Pathology)
Browse Figures
Versions Notes

Abstract

Excessive alcohol consumption can cause alcoholic myopathy, but the molecular mechanism is still unclear. In this study, zebrafish were exposed to 0.5% alcohol for eight weeks to investigate the effect of alcohol on skeletal muscle and its molecular mechanism. The results showed that the body length, body weight, cross-sectional area of the skeletal muscle fibers, Ucrit, and MO2max of the zebrafish were significantly decreased after alcohol exposure. The expression of markers of skeletal muscle atrophy and autophagy was increased, and the expression of P62 was significantly reduced. The content of ROS, the mRNA expression of sod1 and sod2, and the protein expression of Nox2 were significantly increased. In addition, we found that the inflammatory factors Il1β and Tnfα were significantly enriched in skeletal muscle, and the expression of the HMGB1/TLR4/NF-κB signaling axis was also significantly increased. In summary, in this study, we established a zebrafish model of alcohol-induced skeletal muscle atrophy and further elucidated its pathogenesis.
Keywords: zebrafish; alcoholic myopathy; skeletal muscle atrophy; inflammatory zebrafish; alcoholic myopathy; skeletal muscle atrophy; inflammatory

Share and Cite

MDPI and ACS Style

Wen, W.; Sun, C.; Chen, Z.; Yang, D.; Zhou, Z.; Peng, X.; Tang, C. Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling. Life 2022, 12, 1211. https://doi.org/10.3390/life12081211

AMA Style

Wen W, Sun C, Chen Z, Yang D, Zhou Z, Peng X, Tang C. Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling. Life. 2022; 12(8):1211. https://doi.org/10.3390/life12081211

Chicago/Turabian Style

Wen, Wei, Chenchen Sun, Zhanglin Chen, Dong Yang, Zuoqiong Zhou, Xiyang Peng, and Changfa Tang. 2022. "Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling" Life 12, no. 8: 1211. https://doi.org/10.3390/life12081211

APA Style

Wen, W., Sun, C., Chen, Z., Yang, D., Zhou, Z., Peng, X., & Tang, C. (2022). Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling. Life, 12(8), 1211. https://doi.org/10.3390/life12081211

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop