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10.3390/life12111881
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Article

Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population

by
Sithembiso Tiyandza Dlamini
1,
Kyaw Moe Htet
1,
Ei Chue Chue Theint
1,
Wei-Ming Li
2,3,4,
Hsin-Wen Chang
5,6,*,† and
Hung-Pin Tu
7,8,*,†
1
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
3
Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Department of Urology, Ministry of Health and Welfare, Pingtung Hospital, Pingtung 900, Taiwan
5
Department of Applied Psychology, Hsuan Chuang University, 48 Hsuan Chuang Rd., Hsinchu City 30092, Taiwan
6
Center for General Education, Hsuan Chuang University, Hsinchu City 30092, Taiwan
7
Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan
8
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2022, 12(11), 1881; https://doi.org/10.3390/life12111881
Submission received: 24 October 2022 / Revised: 11 November 2022 / Accepted: 11 November 2022 / Published: 14 November 2022
(This article belongs to the Special Issue Feature Paper in Physiology and Pathology)
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Abstract

We investigated the role of vitamin D in the risk of tuberculosis (TB) among patients with end-stage kidney disease (ESKD). The retrospective cohort was conducted with data of 20,985 patients with kidney disease and 20,985 controls without kidney disease (1:1 matching on age of cohort entry and sex) in the duration of 1997–2010 from the Taiwan National Health insurance database. Then, by a case–cohort study, among 20,985 kidney disease, 3194 ESKD patients were identified with matched 3194 non-ESKD patients. Multivariate analyses revealed a significant association between kidney disease and tuberculosis (adjusted incidence rate ratio (IRR) 1.57 (1.33–1.86)), and the risk increased after 3 years of follow-up the (adjusted IRR 3.79 (2.55–5.62)), but after more years of follow-up no significance was observed. We also found that ESKD increases the risk of tuberculosis (adjusted IRR 3.67 (2.27–5.93)). However, vitamin D usage was not related with the tuberculosis risk in ESKD patients (p > 0.1783). Our study showed increased risk of tuberculosis in kidney disease and ESKD patients, and vitamin D was not beneficial in ESKD.
Keywords: retrospective cohort study; kidney disease; end-stage kidney disease; vitamin D; tuberculosis retrospective cohort study; kidney disease; end-stage kidney disease; vitamin D; tuberculosis

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MDPI and ACS Style

Dlamini, S.T.; Htet, K.M.; Theint, E.C.C.; Li, W.-M.; Chang, H.-W.; Tu, H.-P. Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population. Life 2022, 12, 1881. https://doi.org/10.3390/life12111881

AMA Style

Dlamini ST, Htet KM, Theint ECC, Li W-M, Chang H-W, Tu H-P. Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population. Life. 2022; 12(11):1881. https://doi.org/10.3390/life12111881

Chicago/Turabian Style

Dlamini, Sithembiso Tiyandza, Kyaw Moe Htet, Ei Chue Chue Theint, Wei-Ming Li, Hsin-Wen Chang, and Hung-Pin Tu. 2022. "Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population" Life 12, no. 11: 1881. https://doi.org/10.3390/life12111881

APA Style

Dlamini, S. T., Htet, K. M., Theint, E. C. C., Li, W.-M., Chang, H.-W., & Tu, H.-P. (2022). Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population. Life, 12(11), 1881. https://doi.org/10.3390/life12111881

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