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Article

Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging

by
Anastasia Margouta
1,†,
Panagiota Anyfanti
1,2,*,†,
Antonios Lazaridis
1,
Barbara Nikolaidou
1,
Konstantinos Mastrogiannis
1,
Anastasia Malliora
1,
Aikaterini Patsatsi
3,
Areti Triantafyllou
1,
Stella Douma
1,
Michael Doumas
4 and
Eugenia Gkaliagkousi
1
1
3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece
2
Second Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
3
2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Medical School Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece
4
2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2022, 12(11), 1796; https://doi.org/10.3390/life12111796
Submission received: 4 October 2022 / Revised: 27 October 2022 / Accepted: 3 November 2022 / Published: 6 November 2022
(This article belongs to the Special Issue Advances in Microvascular Research)
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Abstract

Psoriasis is associated with accelerated rates of cardiovascular disease (CVD). Laser Speckle Contrast Imaging (LSCI) is a novel, non-interventional technique for the dynamic assessment of microvascular endothelial dysfunction, which represents an early precursor of CVD. We investigated whether skin microvascular reactivity is impaired in psoriasis and whether an association exists with large artery stiffening. Skin microvascular reactivity was assessed with LSCI combined with post-occlusive reactive hyperaemia protocol in psoriasis patients and controls in the absence of established CVD. Arterial stiffness and central hemodynamics were assessed throughout a whole 24 h period with the Mobil-O-Graph device. Most LSCI indices of microvascular reactivity were impaired in psoriasis patients (n = 90) compared to controls (n = 45) [baseline flux; occlusion flux; peak-to-baseline magnitude; baseline cutaneous vascular conductance (CVC); percentage increase in CVC, p < 0.001 for all comparisons]. In multivariate analysis, psoriatic disease predicted the above markers independently of classical CVD risk factors. Augmentation index, peripheral pulse pressure, and central systolic/diastolic blood pressure correlated with LSCI microvascular responses in the study population (n = 135). Pulse wave velocity significantly correlated with nearly all LSCI parameters, while the association with baseline flux was independent of CVD risk factors and psoriatic disease in multivariate analysis (beta = 0.096, p = 0.039). This study provides evidence of altered skin microvascular responses in psoriasis by use of LSCI, and interaction with macrovascular dysfunction, before the establishment of overt CVD. A non-interventional approach of skin microcirculation with LSCI might be used as an early indicator of vascular health in psoriasis.
Keywords: microvascular dysfunction; laser speckle contrast imaging; psoriasis; arterial stiffness; pulse wave velocity microvascular dysfunction; laser speckle contrast imaging; psoriasis; arterial stiffness; pulse wave velocity

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MDPI and ACS Style

Margouta, A.; Anyfanti, P.; Lazaridis, A.; Nikolaidou, B.; Mastrogiannis, K.; Malliora, A.; Patsatsi, A.; Triantafyllou, A.; Douma, S.; Doumas, M.; et al. Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging. Life 2022, 12, 1796. https://doi.org/10.3390/life12111796

AMA Style

Margouta A, Anyfanti P, Lazaridis A, Nikolaidou B, Mastrogiannis K, Malliora A, Patsatsi A, Triantafyllou A, Douma S, Doumas M, et al. Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging. Life. 2022; 12(11):1796. https://doi.org/10.3390/life12111796

Chicago/Turabian Style

Margouta, Anastasia, Panagiota Anyfanti, Antonios Lazaridis, Barbara Nikolaidou, Konstantinos Mastrogiannis, Anastasia Malliora, Aikaterini Patsatsi, Areti Triantafyllou, Stella Douma, Michael Doumas, and et al. 2022. "Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging" Life 12, no. 11: 1796. https://doi.org/10.3390/life12111796

APA Style

Margouta, A., Anyfanti, P., Lazaridis, A., Nikolaidou, B., Mastrogiannis, K., Malliora, A., Patsatsi, A., Triantafyllou, A., Douma, S., Doumas, M., & Gkaliagkousi, E. (2022). Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging. Life, 12(11), 1796. https://doi.org/10.3390/life12111796

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