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Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?
Review

Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease

1
Endoscopy Unit, Fondazione Istituto San Raffaele—G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy
2
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90100 Palermo, Italy
3
Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, 20089 Rozzano, Italy
4
Endocrinology Section, PROMISE Department, AOUP Paolo Giaccone, 90127 Palermo, Italy
5
Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, 93100 Caltanissetta, Italy
6
Endoscopy Unit, Department of clinical and experimental medicine, University of Messina, AOUP Policlinico G. Martino, 98125 Messina, Italy
7
Emergency Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy
8
Unit of Gastroenterology, Bolognini Hospital, 24100 Bergamo, Italy
*
Author to whom correspondence should be addressed.
Emanuele Sinagra and Gaia Pellegatta share the 1st authorship.
Academic Editor: Tissa Wijeratne
Life 2021, 11(7), 715; https://doi.org/10.3390/life11070715
Received: 28 May 2021 / Revised: 4 July 2021 / Accepted: 13 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue The Microbiota-Gut-Brain Axis in Neurodegenerative Diseases)
The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and Parkinson’s disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut–brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut–brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke. View Full-Text
Keywords: gut; brain; microbiota; stroke; inflammatory bowel disease gut; brain; microbiota; stroke; inflammatory bowel disease
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MDPI and ACS Style

Sinagra, E.; Pellegatta, G.; Guarnotta, V.; Maida, M.; Rossi, F.; Conoscenti, G.; Pallio, S.; Alloro, R.; Raimondo, D.; Pace, F.; Anderloni, A. Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease. Life 2021, 11, 715. https://doi.org/10.3390/life11070715

AMA Style

Sinagra E, Pellegatta G, Guarnotta V, Maida M, Rossi F, Conoscenti G, Pallio S, Alloro R, Raimondo D, Pace F, Anderloni A. Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease. Life. 2021; 11(7):715. https://doi.org/10.3390/life11070715

Chicago/Turabian Style

Sinagra, Emanuele, Gaia Pellegatta, Valentina Guarnotta, Marcello Maida, Francesca Rossi, Giuseppe Conoscenti, Socrate Pallio, Rita Alloro, Dario Raimondo, Fabio Pace, and Andrea Anderloni. 2021. "Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease" Life 11, no. 7: 715. https://doi.org/10.3390/life11070715

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