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Article

Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice

by 1,2,3,4, 5, 6, 7,8, 1,9,10,11,12,*, 13,14,* and 15,16,*
1
Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan
2
Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan
3
Rheumatology and Immunology Center, China Medical University Hospital, Taichung 408, Taiwan
4
College of Medicine, China Medical University, Taichung 408, Taiwan
5
Bachelor Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung 202301, Taiwan
6
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
7
Department of Medical Research, Tungs’ Taichung Metro Harbor Hospital, Taichung 433, Taiwan
8
Department of Nursing, Jen-Teh Junior College of Medicine and Management, Miaoli 356, Taiwan
9
The iEGG and Animal Biotechnology Center, Institute of Biomedical Science, National Chung-Hsing University, Taichung 402, Taiwan
10
Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
11
Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan
12
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
14
Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
15
Graduate Institute of Integrated Medicine, and Graduate Institute of Acupuncture Science, College of Chinese Medicine, and Chinese Medicine Research Center, China Medical University, Taichung 408, Taiwan
16
Department of Chinese Medicine, China Medical University Hospital, Taichung 408, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Magdalena Chadzińska
Life 2021, 11(6), 530; https://doi.org/10.3390/life11060530
Received: 12 April 2021 / Revised: 3 June 2021 / Accepted: 5 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Regulation of Natural Products to Immunity)
Sjögren’s syndrome (SS) is an inflammatory autoimmune disease primarily affecting the exocrine glands; it has a major impact on patients’ lives. The Chinese herbal formula SS-1 is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu decoction, which exerts anti-inflammatory, immunomodulatory, and antifibrotic effects. Our previous study demonstrated that SS-1 alleviates clinical SS. This study aimed to evaluate the efficacy and mechanism of the Chinese herbal formula SS-1 for salivary gland protein-induced experimental Sjögren’s syndrome (ESS). These results showed that ESS treatment with the Chinese herbal formula SS-1 (1500 mg/kg) significantly alleviated the severity of ESS. We found that SS-1 substantially improved saliva flow rates in SS mice and ameliorated lymphocytic infiltrations in submandibular glands. In addition, salivary gland protein-induced SS in mice treated with SS-1 significantly lowered proinflammatory cytokines (including IFN-γ, IL-6, and IL-17A) in mouse salivary glands and decreased serum anti-M3R autoantibody levels. In addition, we found that CD4+ T cells isolated from SS-1-treated SS mice significantly reduced the percentages of IFN-γ-producing CD4+ T cells (Th1) and IL-17A-producing CD4+ T cells (Th17). Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS. View Full-Text
Keywords: Sjögren’s syndrome; Chinese herbal medicine; SS-1; anti-inflammation; immunomodulation Sjögren’s syndrome; Chinese herbal medicine; SS-1; anti-inflammation; immunomodulation
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MDPI and ACS Style

Wu, P.-C.; Lin, S.-C.; Panny, L.; Chang, Y.-K.; Lin, C.-C.; Tung, Y.-T.; Chang, H.-H. Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice. Life 2021, 11, 530. https://doi.org/10.3390/life11060530

AMA Style

Wu P-C, Lin S-C, Panny L, Chang Y-K, Lin C-C, Tung Y-T, Chang H-H. Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice. Life. 2021; 11(6):530. https://doi.org/10.3390/life11060530

Chicago/Turabian Style

Wu, Po-Chang, Shih-Chao Lin, Lauren Panny, Yu-Kang Chang, Chi-Chien Lin, Yu-Tang Tung, and Hen-Hong Chang. 2021. "Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice" Life 11, no. 6: 530. https://doi.org/10.3390/life11060530

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