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10.3390/life11050453
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Article

Antioxidant Status in the Vitreous of Eyes with Rhegmatogenous Retinal Detachment with and without Proliferative Vitreoretinopathy, Macular Hole and Epiretinal Membrane

by
Agata Pietras-Baczewska
1,*,
Katarzyna Nowomiejska
1,
Agnieszka Brzozowska
2,
Mario Damiano Toro
1,3,
Wojciech Załuska
4,
Małgorzata Sztanke
5,
Krzysztof Sztanke
6 and
Robert Rejdak
1
1
Chair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-059 Lublin, Poland
2
Department of Mathematics and Medical Biostatistics, Medical University of Lublin, 20-059 Lublin, Poland
3
Faculty of Medicine, Collegium Medicum Cardinal Stefan Wyszynski University, 01-815 Warsaw, Poland
4
Department of Nephrology, Medical University of Lublin, 20-059 Lublin, Poland
5
Department of Medical Chemistry, Medical University of Lublin, 20-059 Lublin, Poland
6
Laboratory of Bioorganic Synthesis and Analysis, Chair and Department of Medical Chemistry, Medical University of Lublin, 20-059 Lublin, Poland
*
Author to whom correspondence should be addressed.
Life 2021, 11(5), 453; https://doi.org/10.3390/life11050453
Submission received: 19 April 2021 / Revised: 12 May 2021 / Accepted: 17 May 2021 / Published: 19 May 2021
(This article belongs to the Collection Retinal Disease and Metabolism)
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Abstract

(1) Background: The aim of the study was to test the hypothesis that the antioxidant status in the vitreous body of eyes, which had been vitrectomized due to rhegmatogenous retinal detachment (RRD) with or without proliferative vitreoretinopathy (PVR), is higher than in eyes vitrectomized due to other retinal diseases. (2) Methods: four patient groups were analyzed: 22 eyes of patients with RRD without PVR, 27 eyes with RRD and PVR, 22 eyes with macular hole (MH) and 10 eyes with epiretinal membrane (ERM). Spectrophotometric methods were used to determine the total antioxidant status (TAS) values as well as superoxide dismutase (SOD) and glutathione reductase (GR) activities in the vitreous fluid samples. (3) Results: no significant differences in TAS values and antioxidant enzyme activities were observed among patient with RRD with and without PVR and with MH and ERM. The longer the duration of RRD leading to PVR and better postoperative visual acuity, the higher the TAS level. No significant differences were found between “macula on” and “macula off” subgroups within the RRD group and the RRD combined with PVR group. (4) Conclusions: The preliminary results do not support the thesis that the antioxidant status of vitrectomized eyes is different in patients with RRD with or without PVR in comparison to patients with MH and ERM. In patients with RRD, PVR presence and detached macula do not affect the values of TAS, SOD and GR in the vitreous fluid. The duration of the disease influences TAS in the vitreous in eyes with RRD complicated with PVR.
Keywords: antioxidant status; vitreous body; rhegmatogenous retinal detachment; proliferative vitreoretinopathy antioxidant status; vitreous body; rhegmatogenous retinal detachment; proliferative vitreoretinopathy

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MDPI and ACS Style

Pietras-Baczewska, A.; Nowomiejska, K.; Brzozowska, A.; Toro, M.D.; Załuska, W.; Sztanke, M.; Sztanke, K.; Rejdak, R. Antioxidant Status in the Vitreous of Eyes with Rhegmatogenous Retinal Detachment with and without Proliferative Vitreoretinopathy, Macular Hole and Epiretinal Membrane. Life 2021, 11, 453. https://doi.org/10.3390/life11050453

AMA Style

Pietras-Baczewska A, Nowomiejska K, Brzozowska A, Toro MD, Załuska W, Sztanke M, Sztanke K, Rejdak R. Antioxidant Status in the Vitreous of Eyes with Rhegmatogenous Retinal Detachment with and without Proliferative Vitreoretinopathy, Macular Hole and Epiretinal Membrane. Life. 2021; 11(5):453. https://doi.org/10.3390/life11050453

Chicago/Turabian Style

Pietras-Baczewska, Agata, Katarzyna Nowomiejska, Agnieszka Brzozowska, Mario Damiano Toro, Wojciech Załuska, Małgorzata Sztanke, Krzysztof Sztanke, and Robert Rejdak. 2021. "Antioxidant Status in the Vitreous of Eyes with Rhegmatogenous Retinal Detachment with and without Proliferative Vitreoretinopathy, Macular Hole and Epiretinal Membrane" Life 11, no. 5: 453. https://doi.org/10.3390/life11050453

APA Style

Pietras-Baczewska, A., Nowomiejska, K., Brzozowska, A., Toro, M. D., Załuska, W., Sztanke, M., Sztanke, K., & Rejdak, R. (2021). Antioxidant Status in the Vitreous of Eyes with Rhegmatogenous Retinal Detachment with and without Proliferative Vitreoretinopathy, Macular Hole and Epiretinal Membrane. Life, 11(5), 453. https://doi.org/10.3390/life11050453

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