Next Article in Journal
Oxidative Stress-Induced Alteration of Plant Central Metabolism
Next Article in Special Issue
Zinc Sulfate Stimulates Osteogenic Phenotypes in Periosteum-Derived Cells and Co-Cultures of Periosteum-Derived Cells and THP-1 Cells
Previous Article in Journal
The Biomechanics of Cartilage—An Overview
Previous Article in Special Issue
The Role of Fibrosis in Osteoarthritis Progression
 
 
Article

Treadmill Exercise after Controlled Abnormal Joint Movement Inhibits Cartilage Degeneration and Synovitis

1
Department of Health and Social Services, Health and Social Services, Graduate School of Saitama Prefectural University, Koshigaya, Saitama 343-8540, Japan
2
Department of Physical Therapy, Health and Social Services, Saitama Prefectural University, Koshigaya, Saitama 343-8540, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Nina Ivanovska
Life 2021, 11(4), 303; https://doi.org/10.3390/life11040303
Received: 20 February 2021 / Revised: 24 March 2021 / Accepted: 29 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Osteoarthritis Pathology and Treatment)
Cartilage degeneration is the main pathological component of knee osteoarthritis (OA), but no effective treatment for its control exists. Although exercise can inhibit OA, the abnormal joint movement with knee OA must be managed to perform exercise. Our aims were to determine how controlling abnormal joint movement and treadmill exercise can suppress cartilage degeneration, to analyze the tissues surrounding articular cartilage, and to clarify the effect of treatment. Twelve-week-old ICR mice (n = 24) underwent anterior cruciate ligament transection (ACL-T) surgery on their right knees and were divided into three groups as follows: ACL-T, animals in the walking group subjected to ACL-T; controlled abnormal joint movement (CAJM), and CAJM with exercise (CAJM + Ex) (n = 8/group). Walking-group animals were subjected to treadmill exercise 6 weeks after surgery, including walking for 18 m/min, 30 min/day, 3 days/week for 8 weeks. Safranin-O staining, hematoxylin-eosin staining, and immunohistochemical staining were performed. The OARSI (Osteoarthritis research Society international) score was lower in the CAJM group than in the ACL-T group and was even lower in the CAJM + Ex group. The CAJM group had a lower meniscal injury score than the ACL-T group, and the CAJM + Ex group demonstrated a less severe synovitis than the ACL-T and CAJM groups. The observed difference in the perichondrium tissue damage score depending on the intervention method suggests different therapeutic effects, that normalizing joint motion can solve local problems in the knee joint, and that the anti-inflammatory effect of treadmill exercise can suppress cartilage degeneration. View Full-Text
Keywords: anterior cruciate ligament; cartilage degeneration; controlled abnormal joint movement; osteoarthritis; treadmill exercise anterior cruciate ligament; cartilage degeneration; controlled abnormal joint movement; osteoarthritis; treadmill exercise
Show Figures

Figure 1

MDPI and ACS Style

Oka, Y.; Murata, K.; Ozone, K.; Kano, T.; Minegishi, Y.; Kuro-Nakajima, A.; Arakawa, K.; Kokubun, T.; Kanemura, N. Treadmill Exercise after Controlled Abnormal Joint Movement Inhibits Cartilage Degeneration and Synovitis. Life 2021, 11, 303. https://doi.org/10.3390/life11040303

AMA Style

Oka Y, Murata K, Ozone K, Kano T, Minegishi Y, Kuro-Nakajima A, Arakawa K, Kokubun T, Kanemura N. Treadmill Exercise after Controlled Abnormal Joint Movement Inhibits Cartilage Degeneration and Synovitis. Life. 2021; 11(4):303. https://doi.org/10.3390/life11040303

Chicago/Turabian Style

Oka, Yuichiro, Kenij Murata, Kaichi Ozone, Takuma Kano, Yuki Minegishi, Aya Kuro-Nakajima, Kohei Arakawa, Takanori Kokubun, and Naohiko Kanemura. 2021. "Treadmill Exercise after Controlled Abnormal Joint Movement Inhibits Cartilage Degeneration and Synovitis" Life 11, no. 4: 303. https://doi.org/10.3390/life11040303

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop