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In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229

Eybna Technologies Ltd., Givat Hen 43905, Israel
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Academic Editor: Yi Dai
Life 2021, 11(4), 290; https://doi.org/10.3390/life11040290
Received: 3 March 2021 / Revised: 22 March 2021 / Accepted: 23 March 2021 / Published: 29 March 2021
(This article belongs to the Section Pharmaceutical Science)
The activity of a new, terpene-based formulation, code-named NT-VRL-1, against Human Coronavirus (HCoV) strain 229E was evaluated in human lung fibroblasts (MRC-5 cells), with and without the addition of cannabidiol (CBD). The main constituents in the terpene formulation used for the experiment were beta caryophyllene, eucalyptol, and citral. The tested formulation exhibited an antiviral effect when it was pre-incubated with the host cells prior to virus infection. The combination of NT-VRL-1 with CBD potentiated the antiviral effect better than the positive controls pyrazofurin and glycyrrhizin. There was a strong correlation between the quantitative results from a cell-viability assay and the cytopathic effect seen under the microscope after 72 h. To the best of our knowledge, this is the first report of activity of a combination of terpenes and CBD against a coronavirus. View Full-Text
Keywords: antiviral; HCoV-229E; terpenes; CBD; cannabis; COVID-19 antiviral; HCoV-229E; terpenes; CBD; cannabis; COVID-19
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MDPI and ACS Style

Chatow, L.; Nudel, A.; Nesher, I.; Hayo Hemo, D.; Rozenberg, P.; Voropaev, H.; Winkler, I.; Levy, R.; Kerem, Z.; Yaniv, Z.; Eyal, N. In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229. Life 2021, 11, 290. https://doi.org/10.3390/life11040290

AMA Style

Chatow L, Nudel A, Nesher I, Hayo Hemo D, Rozenberg P, Voropaev H, Winkler I, Levy R, Kerem Z, Yaniv Z, Eyal N. In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229. Life. 2021; 11(4):290. https://doi.org/10.3390/life11040290

Chicago/Turabian Style

Chatow, Lior, Adi Nudel, Iris Nesher, David Hayo Hemo, Perri Rozenberg, Hanna Voropaev, Ilan Winkler, Ronnie Levy, Zohar Kerem, Zohara Yaniv, and Nadav Eyal. 2021. "In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229" Life 11, no. 4: 290. https://doi.org/10.3390/life11040290

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