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Animal Coronaviruses Induced Apoptosis

Department of Biomedical Sciences, University of West Attica, 12243 Athens, Greece
Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Biomedical Research Foundation of the Academy of Athens, Basic Research Center, 11527 Athens, Greece
Institute of Infection & Global Health, University of Liverpool, Liverpool L69 7BE, UK
Authors to whom correspondence should be addressed.
Equally contributed to this work, thus sharing 1st authorship.
Academic Editor: Renate Kunert
Life 2021, 11(3), 185;
Received: 22 January 2021 / Revised: 21 February 2021 / Accepted: 22 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Ecology, Evolution and Epidemiology of Coronaviruses)
Apoptosis is a form of programmed death that has also been observed in cells infected by several viruses. It is considered one of the most critical innate immune mechanisms that limits pathogen proliferation and propagation before the initiation of the adaptive immune response. Recent studies investigating the cellular responses to SARS-CoV and SARS-CoV-2 infection have revealed that coronaviruses can alter cellular homeostasis and promote cell death, providing evidence that the modulation of apoptotic pathways is important for viral replication and propagation. Despite the genetic diversity among different coronavirus clades and the infection of different cell types and several hosts, research studies in animal coronaviruses indicate that apoptosis in host cells is induced by common molecular mechanisms and apoptotic pathways. We summarize and critically review current knowledge on the molecular aspects of cell-death regulation during animal coronaviruses infection and the viral–host interactions to this process. Future research is expected to lead to a better understanding of the regulation of cell death during coronavirus infection. Moreover, investigating the role of viral proteins in this process will help us to identify novel antiviral targets related to apoptotic signaling pathways. View Full-Text
Keywords: animal coronaviruses; apoptosis; apoptotic pathways animal coronaviruses; apoptosis; apoptotic pathways
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MDPI and ACS Style

Gioti, K.; Kottaridi, C.; Voyiatzaki, C.; Chaniotis, D.; Rampias, T.; Beloukas, A. Animal Coronaviruses Induced Apoptosis. Life 2021, 11, 185.

AMA Style

Gioti K, Kottaridi C, Voyiatzaki C, Chaniotis D, Rampias T, Beloukas A. Animal Coronaviruses Induced Apoptosis. Life. 2021; 11(3):185.

Chicago/Turabian Style

Gioti, Katerina, Christine Kottaridi, Chrysa Voyiatzaki, Dimitrios Chaniotis, Theodoros Rampias, and Apostolos Beloukas. 2021. "Animal Coronaviruses Induced Apoptosis" Life 11, no. 3: 185.

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