Peripheral Neuropathy Presents Similar Symptoms and Pathological Changes in Both High-Fat Diet and Pharmacologically Induced Pre- and Diabetic Mouse Models
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Phenotypic Assays
2.3. Plasma Assays
2.4. Western Blot Analysis
2.5. Immunohistochemical (IHC) Staining
2.6. NCV Analysis
2.7. Morphometric Analysis
2.8. Statistical Analysis
3. Results
3.1. STZ Injections and HFD Administration Induce Diabetes-Related Phenotypic Characteristics in Mice
3.2. STZ-Treated Mice Exhibit Deficits in Both Sensory and Motor NCV after 4.5 Months of Diabetes
3.3. STZ Injections and HFD-Feeding Lead to Morphometric and Morphological Changes in Mouse Peripheral Nerves
3.4. STZ/HFD Mice Manifest Impaired Oxidative/Antioxidative Balance in Peripheral Nerves
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Jaroslawska, J.; Korytko, A.; Zglejc-Waszak, K.; Antonowski, T.; Pomianowski, A.S.; Wasowicz, K.; Wojtkiewicz, J.; Juranek, J.K. Peripheral Neuropathy Presents Similar Symptoms and Pathological Changes in Both High-Fat Diet and Pharmacologically Induced Pre- and Diabetic Mouse Models. Life 2021, 11, 1267. https://doi.org/10.3390/life11111267
Jaroslawska J, Korytko A, Zglejc-Waszak K, Antonowski T, Pomianowski AS, Wasowicz K, Wojtkiewicz J, Juranek JK. Peripheral Neuropathy Presents Similar Symptoms and Pathological Changes in Both High-Fat Diet and Pharmacologically Induced Pre- and Diabetic Mouse Models. Life. 2021; 11(11):1267. https://doi.org/10.3390/life11111267
Chicago/Turabian StyleJaroslawska, Julia, Agnieszka Korytko, Kamila Zglejc-Waszak, Tomasz Antonowski, Andrzej S. Pomianowski, Krzysztof Wasowicz, Joanna Wojtkiewicz, and Judyta K. Juranek. 2021. "Peripheral Neuropathy Presents Similar Symptoms and Pathological Changes in Both High-Fat Diet and Pharmacologically Induced Pre- and Diabetic Mouse Models" Life 11, no. 11: 1267. https://doi.org/10.3390/life11111267