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Protein-Coding Genes in Euarchontoglires with Pseudogene Homologs in Humans

1
Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow 127051, Russia
2
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia
3
Faculty of Biology, Lomonosov Moscow State University, Moscow 119192, Russia
*
Author to whom correspondence should be addressed.
Life 2020, 10(9), 192; https://doi.org/10.3390/life10090192
Received: 14 July 2020 / Revised: 23 August 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Section Genetics and Genomics)
An original bioinformatics technique is developed to identify the protein-coding genes in rodents, lagomorphs and nonhuman primates that are pseudogenized in humans. The method is based on per-gene verification of local synteny, similarity of exon-intronic structures and orthology in a set of genomes. It is applicable to any genome set, even with the number of genomes exceeding 100, and efficiently implemented using fast computer software. Only 50 evolutionary recent human pseudogenes were predicted. Their functional homologs in model species are often associated with the immune system or digestion and mainly express in the testes. According to current evidence, knockout of most of these genes leads to an abnormal phenotype. Some genes were pseudogenized or lost independently in human and nonhuman hominoids. View Full-Text
Keywords: recently pseudogenized genes; human pseudogenes; efficient software; independent pseudogenization in hominoids; Euarchontoglires group recently pseudogenized genes; human pseudogenes; efficient software; independent pseudogenization in hominoids; Euarchontoglires group
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MDPI and ACS Style

Rubanov, L.I.; Zverkov, O.A.; Shilovsky, G.A.; Seliverstov, A.V.; Lyubetsky, V.A. Protein-Coding Genes in Euarchontoglires with Pseudogene Homologs in Humans. Life 2020, 10, 192. https://doi.org/10.3390/life10090192

AMA Style

Rubanov LI, Zverkov OA, Shilovsky GA, Seliverstov AV, Lyubetsky VA. Protein-Coding Genes in Euarchontoglires with Pseudogene Homologs in Humans. Life. 2020; 10(9):192. https://doi.org/10.3390/life10090192

Chicago/Turabian Style

Rubanov, Lev I., Oleg A. Zverkov, Gregory A. Shilovsky, Alexandr V. Seliverstov, and Vassily A. Lyubetsky 2020. "Protein-Coding Genes in Euarchontoglires with Pseudogene Homologs in Humans" Life 10, no. 9: 192. https://doi.org/10.3390/life10090192

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