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Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

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Department of Orthodontics, Kermanshah University of Medical Sciences, 6713954658 Kermanshah, Iran
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Medical Biology Research Center, Kermanshah University of Medical Sciences, 6714415185 Kermanshah, Iran
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Sleep Disorders Research Center, Kermanshah University of Medical Sciences, 6719851115 Kermanshah, Iran
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Students Research Committee, Kermanshah University of Medical Sciences, 6715847141 Kermanshah, Iran
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Center for Affective, Stress and Sleep Disorders, University of Basel, Psychiatric Clinics, 4001 Basel, Switzerland
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Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, 6715847141 Kermanshah, Iran
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Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35209, USA
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Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, 4052 Basel, Switzerland
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School of Medicine, Tehran University of Medical Sciences, 1416753955 Tehran, Iran
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Author to whom correspondence should be addressed.
Life 2020, 10(6), 87; https://doi.org/10.3390/life10060087
Received: 22 April 2020 / Revised: 2 June 2020 / Accepted: 9 June 2020 / Published: 12 June 2020
Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to 1 February 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma. View Full-Text
Keywords: obstructive sleep apnea syndrome; cytokine; tumor necrosis factor alpha; serum; plasma; meta-analysis; meta-regression obstructive sleep apnea syndrome; cytokine; tumor necrosis factor alpha; serum; plasma; meta-analysis; meta-regression
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Imani, M.M.; Sadeghi, M.; Khazaie, H.; Emami, M.; Sadeghi Bahmani, D.; Brand, S. Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression. Life 2020, 10, 87.

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