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Article

Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial

by
Gabriela Angelova
1,
Tereza Skodova
2,
Terezie Prokopiusova
1,
Magdalena Markova
1,
Natalia Hruskova
1,
Marie Prochazkova
1,
Marketa Pavlikova
1,
Sarka Spanhelova
3,
Ivana Stetkarova
4,
Marie Bicikova
2,
Lucie Kolatorova
2 and
Kamila Rasova
1,*
1
Department of Rehabilitation Medicine, Third Faculty of Medicine, Charles University, Ruska 87, 10000 Prague 10, Czech Republic
2
Department of Steroids and Proteofactors, Institute of Endocrionology, 11694 Prague, Czech Republic
3
Department of Rehabilitation and Sport Medicine, Motol University Hospital, V Uvalu 84, 150 06 Prague 5, Czech Republic
4
Department of Neurology, Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Life 2020, 10(11), 267; https://doi.org/10.3390/life10110267
Submission received: 4 September 2020 / Revised: 16 October 2020 / Accepted: 29 October 2020 / Published: 31 October 2020
(This article belongs to the Section Medical Research)
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Abstract

Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system. In this study, the effect of neuroproprioceptive facilitation and inhibition physical therapy on clinical outcomes and neuroactive steroids production in people with multiple sclerosis was evaluated. Moreover, we were interested in the factors that influence the treatment effect. Methods: In total, 44 patients with multiple sclerosis were randomly divided into two groups. Each group underwent a different kind of two months ambulatory therapy (Motor program activating therapy and Vojta’s reflex locomotion). During the following two months, participants were asked to continue the autotherapy. Primary (serum level of cortisol, cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, DHEA) and secondary (balance, cognition and patient-reported outcomes) outcomes were examined three times (pre, post, and washout assessments). Results: In both groups, there is a decreasing trend of 7-oxo-DHEA concentration in post-assessment and 7β-OH-DHEA in washout versus pre-assessment. A higher impact on neuroactive steroids is visible after Vojta’s reflex locomotion. As for clinical outcomes, the Paced Auditory Serial Addition Test and Multiple Sclerosis Impact Scale significantly improved between post-assessment and washout assessment. The improvement was similar for both treatments. Conclusions: Neuroproprioceptive facilitation and inhibition improved the clinical outcomes and led to non-significant changes in neuroactive steroids. Trial registration (NCT04379193).
Keywords: multiple sclerosis; physical therapy; neuroproprioceptive facilitation and inhibition; neuroactive steroids; dehydroepiandrosterone; cortisol multiple sclerosis; physical therapy; neuroproprioceptive facilitation and inhibition; neuroactive steroids; dehydroepiandrosterone; cortisol

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MDPI and ACS Style

Angelova, G.; Skodova, T.; Prokopiusova, T.; Markova, M.; Hruskova, N.; Prochazkova, M.; Pavlikova, M.; Spanhelova, S.; Stetkarova, I.; Bicikova, M.; et al. Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial. Life 2020, 10, 267. https://doi.org/10.3390/life10110267

AMA Style

Angelova G, Skodova T, Prokopiusova T, Markova M, Hruskova N, Prochazkova M, Pavlikova M, Spanhelova S, Stetkarova I, Bicikova M, et al. Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial. Life. 2020; 10(11):267. https://doi.org/10.3390/life10110267

Chicago/Turabian Style

Angelova, Gabriela, Tereza Skodova, Terezie Prokopiusova, Magdalena Markova, Natalia Hruskova, Marie Prochazkova, Marketa Pavlikova, Sarka Spanhelova, Ivana Stetkarova, Marie Bicikova, and et al. 2020. "Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial" Life 10, no. 11: 267. https://doi.org/10.3390/life10110267

APA Style

Angelova, G., Skodova, T., Prokopiusova, T., Markova, M., Hruskova, N., Prochazkova, M., Pavlikova, M., Spanhelova, S., Stetkarova, I., Bicikova, M., Kolatorova, L., & Rasova, K. (2020). Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial. Life, 10(11), 267. https://doi.org/10.3390/life10110267

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