CGSTA-Net: A Cross-Domain Generative Prior-Assisted Structure–Texture Adaptive Network for Remote Sensing Image Dehazing
Abstract
1. Introduction
2. Related Work
2.1. Prior-Based Dehazing Methods
2.2. Learning-Based Dehazing Methods
2.2.1. Parameter Estimation Methods
2.2.2. End-to-End Restoration Methods
2.3. Recent Intelligent Learning Frameworks
2.4. Generative Priors for Image Restoration
2.5. Contrastive Learning Mechanism
3. Method
3.1. Overall Architecture
3.2. HWD
3.3. STCB
3.3.1. MFMSA
3.3.2. MSCA
3.4. PGAF
3.5. Loss Function
4. Experiments
4.1. Experimental Settings
4.1.1. Datasets
4.1.2. Implementation Details
4.1.3. Evaluation Metrics
4.2. Comparison with State-of-the-Art Methods
4.2.1. Quantitative Evaluation
4.2.2. Qualitative Evaluation
4.3. Ablation Study
4.3.1. Effectiveness of Generative Prior and PGAF
4.3.2. Effectiveness of STCB and HWD
4.3.3. Effectiveness of PCL
5. Conclusions and Discussion
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- García, A.A. Relationship between Blue Economy, Cruise Tourism, and Urban Regeneration: Case Study of Olbia, Sardinia. J. Urban Plan. Dev. 2021, 147, 05021029. [Google Scholar] [CrossRef]
- Kulk, G.; Platt, T.; Dingle, J.; Jackson, T.; Jönsson, B.F.; Bouman, H.A.; Babin, M.; Brewin, R.J.W.; Doblin, M.; Estrada, M.; et al. Primary Production, an Index of Climate Change in the Ocean: Satellite-Based Estimates over Two Decades. Remote Sens. 2020, 12, 826, Correction in Remote Sens. 2021, 13, 3462. https://doi.org/10.3390/rs13173462. [Google Scholar] [CrossRef]
- Li, S.; Fang, H.; Zhang, Y. Determination of the Leaf Inclination Angle (LIA) through Field and Remote Sensing Methods: Current Status and Future Prospects. Remote Sens. 2023, 15, 946. [Google Scholar] [CrossRef]
- Lai, J.; Kang, X.; Lu, X.; Li, S. Review of Land Observation Satellite Remote Sensing Application Technology with New Generation Artificial Intelligence. Natl. Remote Sens. Bull. 2022, 26, 1530–1546. [Google Scholar] [CrossRef]
- Cantor, A. Optics of the atmosphere–Scattering by molecules and particles. IEEE J. Quantum Electron. 1978, 14, 698–699. [Google Scholar] [CrossRef]
- Narasimhan, S.G.; Nayar, S.K. Vision and the Atmosphere. Int. J. Comput. Vis. 2002, 48, 233–254. [Google Scholar] [CrossRef]
- He, K.; Sun, J.; Tang, X. Single Image Haze Removal Using Dark Channel Prior. IEEE Trans. Pattern Anal. Mach. Intell. 2011, 33, 2341–2353. [Google Scholar] [CrossRef] [PubMed]
- Zhu, Q.; Mai, J.; Shao, L. A Fast Single Image Haze Removal Algorithm Using Color Attenuation Prior. IEEE Trans. Image Process. 2015, 24, 3522–3533. [Google Scholar] [CrossRef]
- Liu, X.; Ma, Y.; Shi, Z.; Chen, J. GridDehazeNet: Attention-Based Multi-Scale Network for Image Dehazing. In 2019 IEEE/CVF International Conference on Computer Vision (ICCV); IEEE: New York, NY, USA, 2019; pp. 7313–7322. [Google Scholar] [CrossRef]
- Qin, X.; Wang, Z.; Bai, Y.; Xie, X.; Jia, H. FFA-Net: Feature Fusion Attention Network for Single Image Dehazing. arXiv 2019, arXiv:1911.07559. [Google Scholar] [CrossRef]
- Wu, H.; Qu, Y.; Lin, S.; Zhou, J.; Qiao, R.; Zhang, Z.; Xie, Y.; Ma, L. Contrastive Learning for Compact Single Image Dehazing. In 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR); IEEE: New York, NY, USA, 2021; pp. 10546–10555. [Google Scholar] [CrossRef]
- Chen, Z.; He, Z.; Lu, Z.M. DEA-Net: Single Image Dehazing Based on Detail-Enhanced Convolution and Content-Guided Attention. IEEE Trans. Image Process. 2024, 33, 1002–1015. [Google Scholar] [CrossRef]
- Lin, D.; Xu, G.; Wang, X.; Wang, Y.; Sun, X.; Fu, K. A Remote Sensing Image Dataset for Cloud Removal. arXiv 2019, arXiv:1901.00600. [Google Scholar] [CrossRef]
- Chi, K.; Yuan, Y.; Wang, Q. Trinity-Net: Gradient-Guided Swin Transformer-Based Remote Sensing Image Dehazing and Beyond. IEEE Trans. Geosci. Remote Sens. 2023, 61, 4702914. [Google Scholar] [CrossRef]
- Zhang, L.; Wang, S. Dense Haze Removal Based on Dynamic Collaborative Inference Learning for Remote Sensing Images. IEEE Trans. Geosci. Remote Sens. 2022, 60, 5631016. [Google Scholar] [CrossRef]
- Berman, D.; Treibitz, T.; Avidan, S. Non-local Image Dehazing. In 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR); IEEE: New York, NY, USA, 2016; pp. 1674–1682. [Google Scholar] [CrossRef]
- Panagopoulos, A.; Wang, C.; Samaras, D.; Paragios, N. Estimating Shadows with the Bright Channel Cue. In Trends and Topics in Computer Vision; Kutulakos, K.N., Ed.; Springer: Berlin/Heidelberg, Germany, 2012; pp. 1–12. [Google Scholar]
- Meng, G.; Wang, Y.; Duan, J.; Xiang, S.; Pan, C. Efficient Image Dehazing with Boundary Constraint and Contextual Regularization. In 2013 IEEE International Conference on Computer Vision; IEEE: New York, NY, USA, 2013; pp. 617–624. [Google Scholar] [CrossRef]
- Yu, T.; Song, K.; Miao, P.; Yang, G.; Yang, H.; Chen, C. Nighttime Single Image Dehazing via Pixel-Wise Alpha Blending. IEEE Access 2019, 7, 114619–114630. [Google Scholar] [CrossRef]
- Cai, B.; Xu, X.; Jia, K.; Qing, C.; Tao, D. DehazeNet: An End-to-End System for Single Image Haze Removal. IEEE Trans. Image Process. 2016, 25, 5187–5198. [Google Scholar] [CrossRef]
- Li, B.; Peng, X.; Wang, Z.; Xu, J.; Feng, D. AOD-Net: All-in-One Dehazing Network. In 2017 IEEE International Conference on Computer Vision (ICCV); IEEE: New York, NY, USA, 2017; pp. 4780–4788. [Google Scholar] [CrossRef]
- Wang, H.; Ding, Y.; Zhou, X.; Yuan, G.; Sun, C. Dehazing of Panchromatic Remote Sensing Images Based on Histogram Features. Remote Sens. 2025, 17, 3479. [Google Scholar] [CrossRef]
- Ning, J.; Zhou, Y.; Liao, X.; Duo, B. Single Remote Sensing Image Dehazing Using Robust Light-Dark Prior. Remote Sens. 2023, 15, 938. [Google Scholar] [CrossRef]
- Chen, D.; He, M.; Fan, Q.; Liao, J.; Zhang, L.; Hou, D.; Yuan, L.; Hua, G. Gated Context Aggregation Network for Image Dehazing and Deraining. In 2019 IEEE Winter Conference on Applications of Computer Vision (WACV); IEEE: New York, NY, USA, 2019; pp. 1375–1383. [Google Scholar] [CrossRef]
- Zheng, Y.; Zhan, J.; He, S.; Dong, J.; Du, Y. Curricular Contrastive Regularization for Physics-Aware Single Image Dehazing. In 2023 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR); IEEE: New York, NY, USA, 2023; pp. 5785–5794. [Google Scholar] [CrossRef]
- Qiu, Y.; Zhang, K.; Wang, C.; Luo, W.; Li, H.; Jin, Z. MB-TaylorFormer: Multi-branch Efficient Transformer Expanded by Taylor Formula for Image Dehazing. In 2023 IEEE/CVF International Conference on Computer Vision (ICCV); IEEE: New York, NY, USA, 2023; pp. 12756–12767. [Google Scholar] [CrossRef]
- Zheng, L.; Li, Y.; Yu, R.; Zhang, K. Efficient Dual-domain Image Dehazing with Haze Prior Perception. arXiv 2025, arXiv:2507.11035. [Google Scholar]
- Li, Y.; Zhang, K.; Wang, F.; Zhao, L. Remote Sensing Image Dehazing via a Local Context-Enriched Transformer (LCEFormer). Remote Sens. 2024, 16, 1422. [Google Scholar] [CrossRef]
- Zhou, Y.; Ning, J.; Liu, W.; Duo, B. A Dehazing Method for UAV Remote Sensing Based on Global and Local Feature Collaboration (UAVD-Net). Remote Sens. 2025, 17, 1688. [Google Scholar] [CrossRef]
- Wang, X.; Yuan, B.; Dong, H.; Hao, Q.; Li, Z. End-to-End Multi-Scale Adaptive Remote Sensing Image Dehazing Network. Sensors 2025, 25, 218. [Google Scholar] [CrossRef]
- Jin, H.; Chen, Z.; Song, Z.; Sun, K. DFFNet: A Dual-Domain Feature Fusion Network for Single Remote Sensing Image Dehazing. Sensors 2025, 25, 5125. [Google Scholar] [CrossRef] [PubMed]
- Tsai, Y.H.H.; Bai, S.; Liang, P.P.; Kolter, J.Z.; Morency, L.P.; Salakhutdinov, R. Multimodal Transformer for Unaligned Multimodal Language Sequences. In Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics; Association for Computational Linguistics: Florence, Italy, 2019; pp. 6558–6569. [Google Scholar] [CrossRef]
- Woo, S.; Park, J.; Lee, J.Y.; Kweon, I.S. CBAM: Convolutional Block Attention Module. In Computer Vision—ECCV 2018; Springer: Cham, Switzerland, 2018; pp. 3–19. [Google Scholar]
- Zamir, S.W.; Arora, A.; Khan, S.; Hayat, M.; Khan, F.S.; Yang, M.H. Restormer: Efficient Transformer for High-Resolution Image Restoration. In Proceedings of the CVPR 2022, New Orleans, LA, USA, 21–24 June 2022. [Google Scholar]
- Vaswani, A.; Shazeer, N.; Parmar, N.; Uszkoreit, J.; Jones, L.; Gomez, A.N.; Kaiser, Ł.; Polosukhin, I. Attention is All You Need. In Advances in Neural Information Processing Systems 30; Curran Associates, Inc.: Red Hook, NY, USA, 2017; pp. 5998–6008. [Google Scholar]
- Lee-Thorp, J.; Ainslie, J.; Eckstein, I.; Ontañón, S. FNet: Mixing Tokens with Fourier Transforms. In Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies; Association for Computational Linguistics: Seattle, WA, USA, 2022; pp. 4296–4313. [Google Scholar] [CrossRef]
- Mehta, S.; Rastegari, M. MobileViT: Light-weight, General-purpose, and Mobile-friendly Vision Transformer. In Proceedings of the International Conference on Learning Representations, Virtual Event, 25–29 April 2022. [Google Scholar]
- Isola, P.; Zhu, J.Y.; Zhou, T.; Efros, A.A. Image-to-Image Translation with Conditional Adversarial Networks. In 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR); IEEE: New York, NY, USA, 2017; pp. 5967–5976. [Google Scholar] [CrossRef]
- Zhu, J.Y.; Park, T.; Isola, P.; Efros, A.A. Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks. In 2017 IEEE International Conference on Computer Vision (ICCV); IEEE: New York, NY, USA, 2017. [Google Scholar]
- Jiang, S.; Mei, Y.; Wang, P.; Liu, Q. Exposure difference network for low-light image enhancement. Pattern Recognit. 2024, 156, 110796. [Google Scholar] [CrossRef]
- Liu, P.; Zhang, H.; Zhang, K.; Lin, L.; Zuo, W. Multi-level Wavelet-CNN for Image Restoration. In 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW); IEEE: New York, NY, USA, 2018; pp. 886–88609. [Google Scholar] [CrossRef]
- Paszke, A.; Gross, S.; Massa, F.; Lerer, A.; Bradbury, J.; Chanan, G.; Killeen, T.; Lin, Z.; Gimelshein, N.; Antiga, L.; et al. PyTorch: An Imperative Style, High-Performance Deep Learning Library. arXiv 2019, arXiv:1912.01703. [Google Scholar]
- Kingma, D.P.; Ba, J. Adam: A Method for Stochastic Optimization. arXiv 2014, arXiv:1412.6980. [Google Scholar]
- Loshchilov, I.; Hutter, F. SGDR: Stochastic Gradient Descent with Warm Restarts. arXiv 2016, arXiv:1608.03983. [Google Scholar]
- Huynh-Thu, Q.; Ghanbari, M. Scope of validity of PSNR in image/video quality assessment. Electron. Lett. 2008, 44, 800–801. [Google Scholar] [CrossRef]
- Wang, Z.; Bovik, A.; Sheikh, H.; Simoncelli, E. Image quality assessment: From error visibility to structural similarity. IEEE Trans. Image Process. 2004, 13, 600–612. [Google Scholar] [CrossRef]
- Zhang, R.; Isola, P.; Efros, A.A.; Shechtman, E.; Wang, O. The Unreasonable Effectiveness of Deep Features as a Perceptual Metric. In 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition; IEEE: New York, NY, USA, 2018; pp. 586–595. [Google Scholar] [CrossRef]
- Shao, Y.; Li, L.; Ren, W.; Gao, C.; Sang, N. Domain Adaptation for Image Dehazing. In 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR); IEEE: New York, NY, USA, 2020; pp. 2805–2814. [Google Scholar] [CrossRef]
- Lu, L.; Xiong, Q.; Xu, B.; Chu, D. MixDehazeNet: Mix Structure Block for Image Dehazing Network. In 2024 International Joint Conference on Neural Networks (IJCNN); IEEE: New York, NY, USA, 2024; pp. 1–10. [Google Scholar] [CrossRef]
- Li, H.; Liu, H.; Liu, M.; Xiao, Y.; Li, P.; Zan, G. U-Net-Like Spiking Neural Networks for Single Image Dehazing. In 2025 International Joint Conference on Neural Networks (IJCNN); IEEE: New York, NY, USA, 2025; pp. 1–9. [Google Scholar] [CrossRef]











| Dataset | Pixel Resolution | Pixel Count | Spatial Resolution |
|---|---|---|---|
| RICE-I | 262,144 | ∼5 m | |
| RSID | 262,144 | ||
| HRSD | 262,144 |
| Parameter | Setting |
|---|---|
| Data augmentation | Random crop and horizontal flip |
| Patch size | |
| Optimizer | Adam [43] |
| Learning rate scheduler | Cosine annealing [44] |
| Learning rate | to |
| Batch size | 16 |
| Training epochs | 200 |
| Methods | RICE-I | RSID | ||||||
|---|---|---|---|---|---|---|---|---|
| PSNR | SSIM | LPIPS | Runtime | PSNR | SSIM | LPIPS | Runtime | |
| AOD-Net [21] (2017) | 14.72 | 0.6584 | 0.2452 | 0.0009 | 18.22 | 0.8354 | 0.1816 | 0.0011 |
| GCA-Net [24] (2019) | 18.34 | 0.7361 | 0.3879 | 0.1843 | 17.49 | 0.8005 | 0.2358 | 0.0494 |
| DAD [48] (2020) | 20.94 | 0.8623 | 0.2140 | 0.0695 | 16.02 | 0.7680 | 0.2767 | 0.0186 |
| FFA-Net [10] (2020) | 19.89 | 0.8172 | 0.1790 | 0.6733 | 18.68 | 0.8536 | 0.1564 | 0.1773 |
| C2PNet [25] (2023) | 20.20 | 0.8777 | 0.1485 | 5.1203 | 19.45 | 0.8879 | 0.1378 | 0.5038 |
| MB-TaylorFormer [26] (2023) | 21.67 | 0.8813 | 0.1421 | 1.6406 | 17.96 | 0.8602 | 0.1558 | 0.6703 |
| DEA-Net [12] (2024) | 20.31 | 0.8703 | 0.1301 | 0.0305 | 19.11 | 0.8676 | 0.1405 | 0.0295 |
| MixDehaze [49] (2024) | 20.28 | 0.8551 | 0.1433 | 0.2501 | 18.96 | 0.8626 | 0.1438 | 0.0936 |
| DGFDNet [27] (2025) | 20.77 | 0.8539 | 0.1539 | 0.0340 | 18.15 | 0.8471 | 0.1613 | 0.0274 |
| DenseSNN [50] (2025) | 18.64 | 0.8388 | 0.2960 | 0.2305 | 19.27 | 0.8576 | 0.1666 | 0.1376 |
| Ours | 24.52 | 0.8983 | 0.1264 | 1.2651 | 23.91 | 0.9086 | 0.1023 | 0.0803 |
| Methods | LHID-A | LHID-B | ||||||
|---|---|---|---|---|---|---|---|---|
| PSNR | SSIM | LPIPS | Runtime | PSNR | SSIM | LPIPS | Runtime | |
| AOD-Net [21] | 20.74 | 0.8070 | 0.1889 | 0.0010 | 20.48 | 0.8396 | 0.1887 | 0.0012 |
| GCA-Net [24] | 20.34 | 0.7880 | 0.2403 | 0.1998 | 22.52 | 0.8606 | 0.1725 | 0.1976 |
| DAD [48] | 16.37 | 0.7184 | 0.2726 | 0.0619 | 17.33 | 0.7907 | 0.2108 | 0.0652 |
| FFA-Net [10] | 14.29 | 0.6999 | 0.2413 | 0.7220 | 14.44 | 0.7326 | 0.2276 | 0.6854 |
| C2PNet [25] | 18.32 | 0.7747 | 0.1809 | 5.2562 | 19.47 | 0.8204 | 0.1593 | 3.3637 |
| MB-TaylorFormer [26] | 17.90 | 0.7732 | 0.1776 | 1.6469 | 18.86 | 0.8412 | 0.1548 | 1.6406 |
| DEA-Net [12] | 20.58 | 0.8075 | 0.1577 | 0.0384 | 21.68 | 0.8595 | 0.1348 | 0.0378 |
| MixDehaze [49] | 18.01 | 0.7704 | 0.1877 | 0.2607 | 19.76 | 0.8363 | 0.1519 | 0.2875 |
| DGFDNet [27] | 15.25 | 0.7275 | 0.2173 | 0.0398 | 15.26 | 0.7593 | 0.2026 | 0.0416 |
| DenseSNN [50] | 21.83 | 0.8273 | 0.1594 | 0.5658 | 23.63 | 0.8821 | 0.1381 | 0.2080 |
| Ours | 23.60 | 0.8344 | 0.1672 | 1.3982 | 24.91 | 0.8822 | 0.1220 | 1.4066 |
| Methods | DHID | |||
|---|---|---|---|---|
| PSNR | SSIM | LPIPS | Runtime | |
| AOD-Net [21] | 16.90 | 0.7252 | 0.2904 | 0.0036 |
| GCA-Net [24] | 23.42 | 0.8449 | 0.1760 | 0.2301 |
| DAD [48] | 19.65 | 0.8131 | 0.2501 | 0.1002 |
| FFA-Net [10] | 14.25 | 0.6670 | 0.3173 | 1.0277 |
| C2PNet [25] | 16.89 | 0.7388 | 0.2732 | 3.4507 |
| MB-TaylorFormer [26] | 18.27 | 0.7767 | 0.2290 | 3.2166 |
| DEA-Net [12] | 19.09 | 0.7844 | 0.2126 | 0.0706 |
| MixDehaze [49] | 18.29 | 0.7587 | 0.2430 | 0.1048 |
| DGFDNet [27] | 15.29 | 0.6947 | 0.2971 | 0.0920 |
| DenseSNN [50] | 22.81 | 0.8627 | 0.1468 | 0.2190 |
| Ours | 25.32 | 0.8698 | 0.1429 | 1.9418 |
| Training Dataset | Testing Dataset | Fine-Tuning | PSNR ↑ | SSIM ↑ | LPIPS ↓ |
|---|---|---|---|---|---|
| HRSD | RICE-I | No | 16.78 | 0.7225 | 0.1823 |
| HRSD | RSID | No | 18.38 | 0.8467 | 0.1795 |
| AOD-Net | GCA-Net | DAD | FFA-Net | C2PNet | MB-TaylorFormer | DEA-Net | MixDehaze | DGFDNet | DenseSNN | Ours | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FLOPs (G) | 0.114 | 18.565 | 83.595 | 287.533 | 460.954 | 31.819 | 34.043 | 56.482 | 13.454 | 37.270 | 99.969 |
| Parameters (M) | 0.002 | 0.703 | 54.591 | 4.456 | 7.169 | 2.677 | 3.653 | 6.249 | 2.083 | 4.751 | 12.251 |
| Variant | RGB | Prior | HWD | STCB | PGAF | PCL | PSNR ↑ | SSIM ↑ | LPIPS ↓ |
|---|---|---|---|---|---|---|---|---|---|
| RGB base | ✓ | 19.92 | 0.7407 | 0.2555 | |||||
| RGB-Prior base | ✓ | ✓ | 20.58 | 0.7550 | 0.2435 | ||||
| RGB-Prior + PGAF | ✓ | ✓ | ✓ | 21.43 | 0.7794 | 0.2198 | |||
| RGB-Prior + STCB + PGAF | ✓ | ✓ | ✓ | ✓ | 23.71 | 0.8303 | 0.1775 | ||
| RGB-Prior + HWD + PGAF | ✓ | ✓ | ✓ | ✓ | 22.93 | 0.8177 | 0.1683 | ||
| RGB-Prior + HWD + STCB + PGAF | ✓ | ✓ | ✓ | ✓ | ✓ | 24.94 | 0.8591 | 0.1488 | |
| CGSTA-Net | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | 25.32 | 0.8698 | 0.1429 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Li, X.; Zhao, Y.; Niu, N. CGSTA-Net: A Cross-Domain Generative Prior-Assisted Structure–Texture Adaptive Network for Remote Sensing Image Dehazing. Symmetry 2026, 18, 1027. https://doi.org/10.3390/sym18061027
Li X, Zhao Y, Niu N. CGSTA-Net: A Cross-Domain Generative Prior-Assisted Structure–Texture Adaptive Network for Remote Sensing Image Dehazing. Symmetry. 2026; 18(6):1027. https://doi.org/10.3390/sym18061027
Chicago/Turabian StyleLi, Xiaoyan, Yankun Zhao, and Na Niu. 2026. "CGSTA-Net: A Cross-Domain Generative Prior-Assisted Structure–Texture Adaptive Network for Remote Sensing Image Dehazing" Symmetry 18, no. 6: 1027. https://doi.org/10.3390/sym18061027
APA StyleLi, X., Zhao, Y., & Niu, N. (2026). CGSTA-Net: A Cross-Domain Generative Prior-Assisted Structure–Texture Adaptive Network for Remote Sensing Image Dehazing. Symmetry, 18(6), 1027. https://doi.org/10.3390/sym18061027
