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Article

Possibilities of Exploiting Kinetic Control in the Continuous Fractional Crystallization of Diastereomeric Mixtures

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary
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Author to whom correspondence should be addressed.
Academic Editor: György Keglevich
Symmetry 2021, 13(8), 1516; https://doi.org/10.3390/sym13081516
Received: 22 June 2021 / Revised: 21 July 2021 / Accepted: 16 August 2021 / Published: 18 August 2021
(This article belongs to the Collection Feature Papers in Chemistry)
For rapid and kinetic control-influenced resolutions, it is advisable to choose a resolving agent with the highest possible eutectic composition (eeEuResAg). It may also be advantageous to add the crystalline resolving agent directly to the solution of the racemic compound. In addition, the use of a quasi-racemic resolving agent or amphoteric resolving agent can provide kinetic resolution. In some cases, the continuous fractional crystallization of diastereomeric salts requires the salt of the resolving agent (Ca2+, Na+, etc.) or other achiral additives (thiourea) that cause rapid crystallization and provide high diastereomeric purity. A further advantage may be the sequential use of the same resolving agent that is capable of forming crystalline diastereomers with both enantiomers when using kinetic control (tandem resolution). View Full-Text
Keywords: kinetic control; continuous fractional crystallization; diastereomeric salt formation; eutectic composition kinetic control; continuous fractional crystallization; diastereomeric salt formation; eutectic composition
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MDPI and ACS Style

Bánhegyi, D.F.; Fogassy, E.; Pálovics, E. Possibilities of Exploiting Kinetic Control in the Continuous Fractional Crystallization of Diastereomeric Mixtures. Symmetry 2021, 13, 1516. https://doi.org/10.3390/sym13081516

AMA Style

Bánhegyi DF, Fogassy E, Pálovics E. Possibilities of Exploiting Kinetic Control in the Continuous Fractional Crystallization of Diastereomeric Mixtures. Symmetry. 2021; 13(8):1516. https://doi.org/10.3390/sym13081516

Chicago/Turabian Style

Bánhegyi, Dorottya F., Elemér Fogassy, and Emese Pálovics. 2021. "Possibilities of Exploiting Kinetic Control in the Continuous Fractional Crystallization of Diastereomeric Mixtures" Symmetry 13, no. 8: 1516. https://doi.org/10.3390/sym13081516

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