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Open AccessArticle

Riemann-Symmetric-Space-Based Models in Screening for Gene Transfer Polymers

Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 400028 Cluj, Romania
Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
Author to whom correspondence should be addressed.
Symmetry 2019, 11(12), 1466;
Received: 10 October 2019 / Revised: 25 November 2019 / Accepted: 27 November 2019 / Published: 1 December 2019
(This article belongs to the Special Issue Applied Designs in Chemical Structures with High Symmetry)
Today, gene transfer using polymers as transfer vectors is hardly studied. Some polymers have an excellent gene-carrying ability, but their cytotoxic and biocompatibility properties are not suitable for use. Thus, increased insight into the drug space of such structures is needed in the screening for suitable molecules. This study aimed to introduce a mathematical model of polymers suitable for genes transfer. In this regard, Riemann surfaces were used. The concerned polymers were taken from secondary published experimental data. The results show that symmetric Reimann spaces are suitable for further drug screening. The branch point values of Riemann surfaces are especially increased for the polymers suitable in gene transfer. View Full-Text
Keywords: polymers; gene transfer; Riemann space; chemical space; manifold; branching point polymers; gene transfer; Riemann space; chemical space; manifold; branching point
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MDPI and ACS Style

Lungu, C.N.; Grudzinski, I.P. Riemann-Symmetric-Space-Based Models in Screening for Gene Transfer Polymers. Symmetry 2019, 11, 1466.

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