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Symmetry 2018, 10(8), 306;

Study of Morpho-Geometric Variables to Improve the Diagnosis in Keratoconus with Mild Visual Limitation

Department of Graphical Expression, Technical University of Cartagena, 30202 Cartagena, Spain
Department of Physical Chemistry, University of Murcia, 30071 Murcia, Spain
Department of Ophthalmology, Miguel Hernández University of Elche, 03202 Alicante, Spain
Keratoconus Unit of Vissum Corporation Alicante, 03016 Alicante, Spain
Author to whom correspondence should be addressed.
Received: 3 July 2018 / Revised: 19 July 2018 / Accepted: 20 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Symmetry and Engineering Design)
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The validation of new methods for the diagnosis of incipient cases of Keratoconus (KC) with mild visual limitation is of great interest in the field of ophthalmology. During the asymmetric progression of the disease, the current diagnostic indexes do not record the geometric decompensation of the corneal curvature nor the variation of the spatial profile that occurs in singular points of the cornea. The purpose of this work is to determine the structural characterization of the asymmetry of the disease by using morpho-geometric parameters in KC eyes with mild visual limitation including using an analysis of a patient-specific virtual model with the aid of computer-aided design (CAD) tools. This comparative study included 80 eyes of patients classified as mild KC according to the degree of visual limitation and a control group of 122 eyes of normal patients. The metric with the highest area under the receiver operating characteristic (ROC) curve was the posterior apex deviation. The most prominent correlation was found between the anterior and posterior deviations of the thinnest point for the mild keratoconic cases. This new custom computational approach provides the clinician with a three-dimensional view of the corneal architecture when the visual loss starts to impair. View Full-Text
Keywords: geometric model; asymmetric evolution; computer-aided design; corneal topographer geometric model; asymmetric evolution; computer-aided design; corneal topographer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cavas-Martínez, F.; Fernández-Pacheco, D.G.; Cañavate, F.J.F.; Velázquez-Blázquez, J.S.; Bolarín, J.M.; Alió, J.L. Study of Morpho-Geometric Variables to Improve the Diagnosis in Keratoconus with Mild Visual Limitation. Symmetry 2018, 10, 306.

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