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Article

Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. A Randomized Clinical Trial

1
Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Campinas 13000-000, Brazil
2
Private Practice, Erechim 99700-000, Brazil
3
Department of Oral and Implant Surgery, Faculty of Health Sciences, Universidad Católica San Antonio de Murcia, 30107 Guadalupe, Spain
*
Author to whom correspondence should be addressed.
Symmetry 2018, 10(10), 533; https://doi.org/10.3390/sym10100533
Received: 16 September 2018 / Revised: 19 October 2018 / Accepted: 20 October 2018 / Published: 22 October 2018
(This article belongs to the Special Issue Biomaterials and Symmetry)
Objectives: The objective of this study was to evaluate bone reconstruction using xenograft alone and associated with bone marrow aspirate concentrate (BMAC) and hyperbaric oxygen therapy. Material and Methods: Twenty-four maxillary edentulous patients were randomly assigned into three groups: Control group (CG)—xenograft bone alone (n = 8); Group 1 (G1)—xenogeneic bone block combined with BMAC (n = 8), and Group 2 (G2)—xenogeneic bone block combined with BMAC and hyperbaric oxygenation (n = 8). Bone biopsies were harvested 6 months after grafting. Vital Mineralized Tissue (VMT), Non-vital Mineralized Tissue (NVMT), and Non-Mineralized Tissue (NMT) were measured. Computed tomography was also performed on three occasions T0 (preoperative), T4 (4 months postoperative), and T8 (8 months postoperative). The difference between T4 and T8 values with respect to T0 was used to determine the thickness level gain after 4 and 8 months, respectively. Results: The tomographic evaluation did not show significant differences between the groups either at 4 or at the 8 months postoperatively. Regarding the histomorphometric analysis, CG had the lowest percentages of VMT (36.58 ± 9.56%), whereas G1 and G2 had similar results (55.64 ± 2.83% and 55.30 ± 1.41%, respectively). Concerning NMT and NVMT levels, the opposite was observed, with CG levels of 51.21 ± 11.54% and 11.16 ± 2.37%, G1 of 39.76 ± 11.48% and 3.65 ± 0.87%, and G2 of 40.3 ± 11.48% and 4.10 ± 0.87%, respectively. Conclusions: The use of bone block xenograft associated with BMAC resulted in a significant increase of bone neoformation when compared to the xenograft alone, though hyperbaric oxygenation did not enhance the results. View Full-Text
Keywords: maxilla; bone marrow; hyperbaric oxygenation; bone xenograft maxilla; bone marrow; hyperbaric oxygenation; bone xenograft
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MDPI and ACS Style

Aloise, A.C.; Pasquali, P.; Sperandio, M.; Scavone de Macedo, L.G.; Lucchesi Teixeira, M.; Pelegrine, A.A.; Calvo-Guirado, J.L. Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. A Randomized Clinical Trial. Symmetry 2018, 10, 533. https://doi.org/10.3390/sym10100533

AMA Style

Aloise AC, Pasquali P, Sperandio M, Scavone de Macedo LG, Lucchesi Teixeira M, Pelegrine AA, Calvo-Guirado JL. Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. A Randomized Clinical Trial. Symmetry. 2018; 10(10):533. https://doi.org/10.3390/sym10100533

Chicago/Turabian Style

Aloise, Antonio Carlos, Paulo Pasquali, Marcelo Sperandio, Luis Guilherme Scavone de Macedo, Marcelo Lucchesi Teixeira, André Antonio Pelegrine, and José Luis Calvo-Guirado. 2018. "Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. A Randomized Clinical Trial" Symmetry 10, no. 10: 533. https://doi.org/10.3390/sym10100533

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