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Article

Degradation of Losartan in Fresh Urine by Sonochemical and Photochemical Advanced Oxidation Processes

1
Grupo de Investigación en Remediación Ambiental y Biocatálisis (GIRAB), Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Calle Nueva, 050014 Medellín, Colombia
2
Maestría en Ciencias Químicas, Facultad de Tecnología, Universidad Tecnológica de Pereira, 660001 Pereira, Colombia
3
Grupo de Investigación QUIBIO, Facultad de Ciencias Básicas, Universidad Santiago de Cali, Santiago de Cali, 760035 Pampalinda, Colombia
*
Authors to whom correspondence should be addressed.
Water 2020, 12(12), 3398; https://doi.org/10.3390/w12123398
Received: 30 October 2020 / Revised: 26 November 2020 / Accepted: 29 November 2020 / Published: 3 December 2020
In this work, the degradation of the pharmaceutical losartan, in simulated fresh urine (which was considered because urine is the main excretion route for this compound) by sonochemistry and UVC/H2O2 individually, was studied. Initially, special attention was paid to the degrading action of the processes. Then, theoretical analyses on Fukui function indices, to determine electron-rich regions on the pharmaceutical susceptible to attacks by the hydroxyl radical, were performed. Afterward, the ability of the processes to mineralize losartan and remove the phyto-toxicity was tested. It was found that in the sonochemical treatment, hydroxyl radicals played the main degrading role. In turn, in UVC/H2O2, both the light and hydroxyl radical eliminated the target contaminant. The sonochemical system showed the lowest interference for the elimination of losartan in the fresh urine. It was established that atoms in the imidazole of the contaminant were the moieties most prone to primary transformations by radicals. This was coincident with the initial degradation products coming from the processes action. Although both processes exhibited low mineralizing ability toward losartan, the sonochemical treatment converted losartan into nonphytotoxic products. This research presents relevant results on the elimination of a representative pharmaceutical in fresh urine by two advanced oxidation processes. View Full-Text
Keywords: advanced oxidation process; elimination routes; fresh urine; pharmaceutical degradation; processes selectivity; theoretical analysis advanced oxidation process; elimination routes; fresh urine; pharmaceutical degradation; processes selectivity; theoretical analysis
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MDPI and ACS Style

Guateque-Londoño, J.F.; Serna-Galvis, E.A.; Ávila-Torres, Y.; Torres-Palma, R.A. Degradation of Losartan in Fresh Urine by Sonochemical and Photochemical Advanced Oxidation Processes. Water 2020, 12, 3398. https://doi.org/10.3390/w12123398

AMA Style

Guateque-Londoño JF, Serna-Galvis EA, Ávila-Torres Y, Torres-Palma RA. Degradation of Losartan in Fresh Urine by Sonochemical and Photochemical Advanced Oxidation Processes. Water. 2020; 12(12):3398. https://doi.org/10.3390/w12123398

Chicago/Turabian Style

Guateque-Londoño, John F., Efraím A. Serna-Galvis, Yenny Ávila-Torres, and Ricardo A. Torres-Palma 2020. "Degradation of Losartan in Fresh Urine by Sonochemical and Photochemical Advanced Oxidation Processes" Water 12, no. 12: 3398. https://doi.org/10.3390/w12123398

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