The Establishment of the Household Air Pollution Consortium (HAPCO)
by
H. Dean Hosgood III 1,*
, Madelyn Klugman 1, Keitaro Matsuo 2, Alexandra J. White 3, Atsuko Sadakane 4, Xiao-Ou Shu 5, Ruy Lopez-Ridaura 6, Aesun Shin 7, Ichiro Tsuji 8, Reza Malekzadeh 9, Nolwenn Noisel 10, Parveen Bhatti 11, Gong Yang 12, Eiko Saito 13, Shafiur Rahman 14, Wei Hu 15, Bryan Bassig 15, George Downward 16, Roel Vermeulen 16, Xiaonan Xue 1, Thomas Rohan 1, Sarah K. Abe 17, Philippe Broët 10, Eric J. Grant 4, Trevor J. B. Dummer 18, Nat Rothman 15, Manami Inoue 17, Martin Lajous 6,19, Keun-Young Yoo 7, Hidemi Ito 2, Dale P. Sandler 3, Habib Ashan 20,†, Wei Zheng 12,†, Paolo Boffetta 21,22,† and Qing Lan 15,†
H. Dean Hosgood III 1,*, Madelyn Klugman 1, Keitaro Matsuo 2, Alexandra J. White 3, Atsuko Sadakane 4, Xiao-Ou Shu 5, Ruy Lopez-Ridaura 6, Aesun Shin 7, Ichiro Tsuji 8, Reza Malekzadeh 9, Nolwenn Noisel 10, Parveen Bhatti 11, Gong Yang 12, Eiko Saito 13, Shafiur Rahman 14, Wei Hu 15, Bryan Bassig 15, George Downward 16, Roel Vermeulen 16, Xiaonan Xue 1, Thomas Rohan 1, Sarah K. Abe 17, Philippe Broët 10, Eric J. Grant 4, Trevor J. B. Dummer 18, Nat Rothman 15, Manami Inoue 17, Martin Lajous 6,19, Keun-Young Yoo 7, Hidemi Ito 2, Dale P. Sandler 3, Habib Ashan 20,†, Wei Zheng 12,†, Paolo Boffetta 21,22,† and Qing Lan 15,†
1
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
2
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; Nagoya 464-8681, Japan
3
Epidemiology Branch, National Institute of Environmental Health Science, Research Triangle Park, NC 27709, USA
4
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan
5
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medicine Center, Nashville, TN 37203-1738, USA
6
National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico
7
Department of Preventative Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
8
Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan
9
Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran 14117, Iran
10
CARTaGENE, Centre de Recherche du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada
11
BC Cancer, Vancouver, BC V5Z 1L3, Canada
12
Center for Health Services, Vanderbilt University School of Medicine, Nashville, TN 37203-1738, USA
13
Division of Cancer Statistics and Integration, Center for Cancer Control and Information Services, National Cancer Center, Tokyo 104-0045, Japan
14
Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan
15
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA
16
Institute for Risk Assessment Services, Utrecht University, 3508 Utrecht, The Netherlands
17
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan
18
School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
19
Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
20
Department of Health Sciences, The University of Chicago, Chicago, IL 60637, USA
21
The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
22
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
†
These authors share senior authorship.
Atmosphere 2019, 10(7), 422; https://doi.org/10.3390/atmos10070422
Received: 30 May 2019 / Revised: 3 July 2019 / Accepted: 17 July 2019 / Published: 23 July 2019
(This article belongs to the Special Issue Household Cooking and Space Heating: Effects on Air Pollution, Climate Change, and Human Health)
Household air pollution (HAP) is of public health concern, with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from biomass use, primarily wood, is not conclusive. To robustly assess biomass’s carcinogenic potential, prospective studies of individuals experiencing a variety of HAP exposures are needed. We have built a global consortium of 13 prospective cohorts (HAPCO: Household Air Pollution Consortium) that have site- and disease-specific mortality and solid fuel use data, for a combined sample size of 587,257 participants and 57,483 deaths. HAPCO provides a novel opportunity to assess the association of HAP with lung cancer death while controlling for important confounders such as tobacco and outdoor air pollution exposures. HAPCO is also uniquely positioned to determine the risks associated with cancers other than lung as well as nonmalignant respiratory and cardiometabolic outcomes, for which prospective epidemiologic research is limited. HAPCO will facilitate research to address public health concerns associated with HAP-attributed exposures by enabling investigators to evaluate sex-specific and smoking status-specific effects under various exposure scenarios.
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Keywords:
pollution; environmental exposures; biomass; cohort studies; consortium; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Hosgood, H.D., III; Klugman, M.; Matsuo, K.; White, A.J.; Sadakane, A.; Shu, X.-O.; Lopez-Ridaura, R.; Shin, A.; Tsuji, I.; Malekzadeh, R.; Noisel, N.; Bhatti, P.; Yang, G.; Saito, E.; Rahman, S.; Hu, W.; Bassig, B.; Downward, G.; Vermeulen, R.; Xue, X.; Rohan, T.; Abe, S.K.; Broët, P.; Grant, E.J.; Dummer, T.J.B.; Rothman, N.; Inoue, M.; Lajous, M.; Yoo, K.-Y.; Ito, H.; Sandler, D.P.; Ashan, H.; Zheng, W.; Boffetta, P.; Lan, Q. The Establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere 2019, 10, 422.
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