Genes 2018, 9(9), 448; https://doi.org/10.3390/genes9090448
Epigenetic Control of Pancreatic Regeneration in Diabetes
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France
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Received: 31 July 2018 / Revised: 31 August 2018 / Accepted: 3 September 2018 / Published: 7 September 2018
(This article belongs to the Special Issue Advances in Genetics of Regeneration in Metabesity)
Abstract
Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development, making use of diverse cell sources or converting pre-existing pancreatic cells. Despite impressive progresses and promising successes, it appears that we still need to gain further insight into the molecular mechanisms underlying β-cell development. This becomes even more obvious with the emergence of a relatively new field of research, epigenetics. The current review therefore focuses on the latest advances in this field in the context of β-cell (neo-)genesis research. View Full-TextKeywords:
epigenetics; pancreas; regeneration; diabetes
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Balaji, S.; Napolitano, T.; Silvano, S.; Friano, M.E.; Garrido-Utrilla, A.; Atlija, J.; Collombat, P. Epigenetic Control of Pancreatic Regeneration in Diabetes. Genes 2018, 9, 448.
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