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Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis

Pró–Reitoria de Pesquisa e Pós-graduação (PRPPG), Universidade do Sagrado Coração, USC, 10–50 Irmã Arminda, Jardim Brasil, Bauru, SP 17011–160, Brazil
Department of Basic Sciences, São Paulo State University (Unesp), School of Dentistry, Araçatuba, SP 16015-050, Brazil
Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77054, USA
Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA
Authors to whom correspondence should be addressed.
Genes 2018, 9(9), 444;
Received: 23 July 2018 / Revised: 28 August 2018 / Accepted: 31 August 2018 / Published: 6 September 2018
(This article belongs to the Special Issue DNA Variations in Evolution and Human Diseases)
Dental implants provide a predictable treatment option for partial and complete edentulism via the placement of a fixed permanent artificial root to support prosthetic dental crowns. Despite the high survival rates, long-term dental implant failures are still reported, leading to implant removals and additional financial and health burdens. While extrinsic factors that improve the success rate of implants have been well explored, the impact of genetic factors on this matter is poorly understood. A systematic review and meta-analysis study was conducted to determine whether genetic factors contribute to an increased risk of dental implant failures. A comprehensive search for peer-reviewed articles on dental implants and genetic factors was performed using various literature database libraries. The study design was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and the obtained records were registered in the International Prospective Register of Systematic Reviews (PROSPERO) database. According to the exclusion/inclusion criteria, 13 studies were eligible for this study out of 809 articles. The meta-analysis of the combined association studies of DNA variations and dental implants did not indicate an increased risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF-α. This study emphasizes the need for larger randomized controlled clinical trials to inform clinicians and patients about the role of genetic factors on dental implant survival and the success rate in healthy and compromised patients. View Full-Text
Keywords: genetic factors; dental implants; bone quality; bone regeneration; survival rate genetic factors; dental implants; bone quality; bone regeneration; survival rate
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Santiago Junior, J.F.; Biguetti, C.C.; Matsumoto, M.A.; Abu Halawa Kudo, G.; Parra da Silva, R.B.; Pinto Saraiva, P.; Fakhouri, W.D. Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis. Genes 2018, 9, 444.

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