Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites
AbstractThe organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and trafficked into the organelle via a series of translocation complexes. Much of what is known about organelle protein translocation mechanisms is based on studies performed in common model organisms; e.g., yeast and humans or Arabidopsis. However, studies performed in divergent organisms are gradually accumulating. These studies provide insights into universally conserved traits, while discovering traits that are specific to organisms or clades. Apicomplexan parasites feature two organelles of endosymbiotic origin: a secondary plastid named the apicoplast and a mitochondrion. In the context of the diseases caused by apicomplexan parasites, the essential roles and divergent features of both organelles make them prime targets for drug discovery. This potential and the amenability of the apicomplexan Toxoplasma gondii to genetic manipulation motivated research about the mechanisms controlling both organelles’ biogenesis. Here we provide an overview of what is known about apicomplexan organelle protein import. We focus on work done mainly in T. gondii and provide a comparison to model organisms. View Full-Text
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Mallo, N.; Fellows, J.; Johnson, C.; Sheiner, L. Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites. Genes 2018, 9, 412.
Mallo N, Fellows J, Johnson C, Sheiner L. Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites. Genes. 2018; 9(8):412.Chicago/Turabian Style
Mallo, Natalia; Fellows, Justin; Johnson, Carla; Sheiner, Lilach. 2018. "Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites." Genes 9, no. 8: 412.
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