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Genetic Mechanisms of Asthma and the Implications for Drug Repositioning

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China
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Genes 2018, 9(5), 237; https://doi.org/10.3390/genes9050237
Received: 12 March 2018 / Revised: 21 April 2018 / Accepted: 26 April 2018 / Published: 3 May 2018
(This article belongs to the Special Issue DNA Variations in Evolution and Human Diseases)
Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics. View Full-Text
Keywords: asthma; disease-susceptible genes; drug repositioning asthma; disease-susceptible genes; drug repositioning
MDPI and ACS Style

Huo, Y.; Zhang, H.-Y. Genetic Mechanisms of Asthma and the Implications for Drug Repositioning. Genes 2018, 9, 237.

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