Next Article in Journal
Integration of lncRNA and mRNA Transcriptome Analyses Reveals Genes and Pathways Potentially Involved in Calf Intestinal Growth and Development during the Early Weeks of Life
Next Article in Special Issue
Overview of Oxidative Stress Response Genes in Selected Halophilic Fungi
Previous Article in Journal
Pyrethroid Resistance in the Major Malaria Vector Anopheles funestus is Exacerbated by Overexpression and Overactivity of the P450 CYP6AA1 Across Africa
Previous Article in Special Issue
The Unexplored Diversity of Pleolipoviruses: The Surprising Case of Two Viruses with Identical Major Structural Modules

The Non-Coding Regulatory RNA Revolution in Archaea

Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
Author to whom correspondence should be addressed.
Genes 2018, 9(3), 141;
Received: 24 January 2018 / Revised: 20 February 2018 / Accepted: 22 February 2018 / Published: 5 March 2018
(This article belongs to the Special Issue Genetics and Genomics of Extremophiles)
Small non-coding RNAs (sRNAs) are ubiquitously found in the three domains of life playing large-scale roles in gene regulation, transposable element silencing and defense against foreign elements. While a substantial body of experimental work has been done to uncover function of sRNAs in Bacteria and Eukarya, the functional roles of sRNAs in Archaea are still poorly understood. Recently, high throughput studies using RNA-sequencing revealed that sRNAs are broadly expressed in the Archaea, comprising thousands of transcripts within the transcriptome during non-challenged and stressed conditions. Antisense sRNAs, which overlap a portion of a gene on the opposite strand (cis-acting), are the most abundantly expressed non-coding RNAs and they can be classified based on their binding patterns to mRNAs (3′ untranslated region (UTR), 5′ UTR, CDS-binding). These antisense sRNAs target many genes and pathways, suggesting extensive roles in gene regulation. Intergenic sRNAs are less abundantly expressed and their targets are difficult to find because of a lack of complete overlap between sRNAs and target mRNAs (trans-acting). While many sRNAs have been validated experimentally, a regulatory role has only been reported for very few of them. Further work is needed to elucidate sRNA-RNA binding mechanisms, the molecular determinants of sRNA-mediated regulation, whether protein components are involved and how sRNAs integrate with complex regulatory networks. View Full-Text
Keywords: small RNAs; sRNAs; non-coding RNAs; ncRNAs; archaea; stress response; gene regulation; RNA-seq small RNAs; sRNAs; non-coding RNAs; ncRNAs; archaea; stress response; gene regulation; RNA-seq
Show Figures

Graphical abstract

MDPI and ACS Style

Gelsinger, D.R.; DiRuggiero, J. The Non-Coding Regulatory RNA Revolution in Archaea. Genes 2018, 9, 141.

AMA Style

Gelsinger DR, DiRuggiero J. The Non-Coding Regulatory RNA Revolution in Archaea. Genes. 2018; 9(3):141.

Chicago/Turabian Style

Gelsinger, Diego R., and Jocelyne DiRuggiero. 2018. "The Non-Coding Regulatory RNA Revolution in Archaea" Genes 9, no. 3: 141.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop