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Genes 2018, 9(3), 143; https://doi.org/10.3390/genes9030143

Overview of Oxidative Stress Response Genes in Selected Halophilic Fungi

Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana, Slovenia
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Received: 31 January 2018 / Revised: 22 February 2018 / Accepted: 27 February 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Genetics and Genomics of Extremophiles)
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Abstract

Exposure of microorganisms to stress, including to high concentrations of salt, can lead to increased production of reactive oxygen species in the cell. To limit the resulting damage, cells have evolved a variety of antioxidant defenses. The role of these defenses in halotolerance has been proposed before. Whole genome sequencing for some of the most halotolerant and halophilic fungal species has enabled us to investigate the possible links between oxidative and salt stress tolerance on the genomic level. We identified genes involved in oxidative stress response in the halophilic basidiomycete Wallemia ichthyophaga, and halotolerant ascomycetous black yeasts Hortaea werneckii and Aureobasidium pullulans, and compared them to genes from 16 other fungi, both asco- and basidiomycetes. According to our results, W. ichthyophaga can survive salinities detrimental to most other organisms with only a moderate number of oxidative stress response genes. In other investigated species, however, the maximum tolerated salinity correlated with the number of genes encoding three major enzymes of the cellular oxidative stress response: superoxide dismutases, catalases, and peroxiredoxins. This observation supports the hypothetical link between the antioxidant capacity of cells and their halotolerance. View Full-Text
Keywords: oxidative stress; reactive oxidative species; halophilic fungi; halotolerant fungi; peroxidase; catalase; Wallemia ichthyophaga; Hortaea werneckii; Aureobasidium pullulans oxidative stress; reactive oxidative species; halophilic fungi; halotolerant fungi; peroxidase; catalase; Wallemia ichthyophaga; Hortaea werneckii; Aureobasidium pullulans
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Gostinčar, C.; Gunde-Cimerman, N. Overview of Oxidative Stress Response Genes in Selected Halophilic Fungi. Genes 2018, 9, 143.

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