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Genes 2018, 9(3), 138; https://doi.org/10.3390/genes9030138

Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies

1
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK
2
CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 January 2018 / Revised: 17 February 2018 / Accepted: 21 February 2018 / Published: 2 March 2018
(This article belongs to the Special Issue Wnt Signaling in Stem Cells)
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Abstract

Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate. In the gastrointestinal tract, Wnt signalling activation drives homeostasis and damage-induced repair. Additionally, deregulated Wnt signalling is a common hallmark of age-associated tissue dysfunction and cancer. Studies using mouse and fruit fly models have greatly improved our understanding of the functional contribution of the Wnt signalling pathway in adult intestinal biology. Here, we summarize the latest knowledge acquired from mouse and Drosophila research regarding canonical Wnt signalling and its key functions during stem cell driven intestinal homeostasis, regeneration, ageing and cancer. View Full-Text
Keywords: Wnt signalling; intestine; homeostasis; regeneration; stem cells; Drosophila; mouse models; cancer Wnt signalling; intestine; homeostasis; regeneration; stem cells; Drosophila; mouse models; cancer
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Perochon, J.; Carroll, L.R.; Cordero, J.B. Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies. Genes 2018, 9, 138.

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